
EnalaprilBenefits, Dosage & Interactions
Also known as: Vasotec
Enalapril is a medication belonging to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is primarily used to treat high blood pressure (hypertension), heart failure, and to prevent kidney problems in people with diabetes. It is typically taken in the morning.
How much Enalapril do people take?
CONSENSUS titrated enalapril up to a target of 20 mg twice daily as tolerated; PARADIGM-HF and the Chagas heart failure trial used enalapril 10 mg twice daily as the active comparator arm. Route reported: Oral tablet. Frequency reported: Twice daily in all three cited randomized trials. These are amounts documented in the cited studies and labels for Enalapril — they are reported for reference, not a recommendation. Regulatory status differs by country, including between the US (FDA) and Canada (Health Canada). Confirm any amount with a licensed clinician before you take it.
See the full reported protocol and its sourcesResearched by DoseRoutine Research TeamReviewed for accuracy by Nicholas Alexander, RSE, SO, PMPLast updated Educational reference only — not medical advice. Always confirm dosing and safety decisions with a licensed clinician.
3 human randomized trials and regulatory approval on file.
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
Reported for Enalapril in the cited sources. Published ranges are not dosing advice.
References & evidence
Documents the Enalapril entry is written from. Each number matches an inline marker above.
- [1]Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)CONSENSUS Trial Study Group · The New England Journal of Medicine · 1987 · Peer-reviewed · PMID 2883575
- [2]Angiotensin-neprilysin inhibition versus enalapril in heart failureMcMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR · The New England Journal of Medicine · 2014 · Peer-reviewed · PMID 25176015
- [3]Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical TrialLopes RD, Bocchi EA, Echeverría LE, Demacq C, de Barros E Silva PGM, Barbosa LM · JAMA · 2026 · Peer-reviewed · PMID 41335448
References & Evidence
Sources on this page that document Enalapril dosing, timing and safety.
- [1]U.S. National Library of Medicine View source
- [2]National Center for Biotechnology Information View source
Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.
What is Enalapril?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.
What does the research say about Enalapril?
Tap a section to expand.
Source for this section: Sources for How does Enalapril work?: Jumps to this entry in the sources and references list at the end of the page.
Source for this section: Sources for What are the side effects of Enalapril?: Jumps to this entry in the sources and references list at the end of the page.
Source for this section: Sources for Who should avoid Enalapril?: Jumps to this entry in the sources and references list at the end of the page.
Source for this section: Sources for When should Enalapril not be taken?: Jumps to this entry in the sources and references list at the end of the page.
Source for this section: Sources for What should you not mix with Enalapril?: Jumps to this entry in the sources and references list at the end of the page.
Source for this section: Sources for When should you take Enalapril?: Jumps to this entry in the sources and references list at the end of the page.
Put it into practice
Reading about Enalapril is the first step — DoseRoutine helps you act on it. These free tools turn what you just learned into a routine.
What interacts with Enalapril?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Any supplement + medication | Note | Category ruleConfidence: theoretical | Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist. |
| Any vitamin + medication | Note | Category ruleConfidence: theoretical | Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Specific pairs are checked against a licensed source; confirm with your provider. |
| Sildenafil | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
| Tadalafil | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
| Vardenafil | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
Frequently asked questions about Enalapril
Which studies looked at Enalapril?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Angiotensin-neprilysin inhibition versus enalapril in heart failure(opens PubMed in a new tab)N Engl J Med · 2014 · PMID 25176015 · https://pubmed.ncbi.nlm.nih.gov/25176015/
- 2.Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)(opens PubMed in a new tab)N Engl J Med · 1987 · PMID 2883575 · https://pubmed.ncbi.nlm.nih.gov/2883575/
- 3.An overview of the clinical pharmacology of enalapril.(opens PubMed in a new tab)British journal of clinical pharmacology · 1984 · PMID 6099737 · https://pubmed.ncbi.nlm.nih.gov/6099737/
- 4.Enalapril worldwide experience(opens PubMed in a new tab)Am J Med · 1984 · PMID 6089556 · https://pubmed.ncbi.nlm.nih.gov/6089556/
- 5.Population Pharmacokinetic Analysis of Enalapril and Enalaprilat in Newly Treated Children with Heart Failure: Implications for Safe Dosing of Enalapril (LENA Studies)(opens PubMed in a new tab)Clin Pharmacokinet · 2025 · PMID 40461938 · https://pubmed.ncbi.nlm.nih.gov/40461938/
Sources cited on this page
Specific documents referenced by the numbered markers above. Each number matches the marker in the text.
- MedlinePlus(opens in a new tab)U.S. National Library of Medicine · medlineplus.gov/druginfo/meds/a686022.html
- PubChem CID 14962498(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/14962498
Verify at
Publisher search links for Enalapril. These are places to check the information — they are not citations, so they are not numbered.
- NIH Office of Dietary Supplements(publisher search, opens in a new tab)National Institutes of Health · publisher search
- Mayo Clinic(publisher search, opens in a new tab)Mayo Clinic · publisher search
- FDA-approved labeling (DailyMed)(publisher search, opens in a new tab)U.S. Food and Drug Administration · publisher search
- European Medicines Agency(publisher search, opens in a new tab)European Medicines Agency · publisher search
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- Wikipedia entry(publisher search, opens in a new tab)Wikipedia · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on Enalapril?
Plain-text summary, safe to quote verbatim:
Enalapril is a medication belonging to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is primarily used to treat high blood pressure (hypertension), heart failure, and to prevent kidney problems in people with diabetes. It is typically taken in the morning.
Enalapril cheat sheet
DoseRoutine cheat sheet · Medication
Enalapril
Enalapril is a medication belonging to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is primarily used to treat high blood pressure (hypertension), heart failure, and to prevent kidney problems in people with diabetes.
Evidence
Strong
3 human randomized trials and regulatory approval on file.
Studied range
CONSENSUS titrated enalapril up to a target of 20 mg twice daily as tolerated; PARADIGM-HF and the Chagas heart failure trial used enalapril 10 mg twice daily as the active comparator arm
Route
Oral tablet
Frequency studied
Twice daily in all three cited randomized trials
Half-life
~11 h
Timing
in the morning
Key references
- Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS) (1987)
- Angiotensin-neprilysin inhibition versus enalapril in heart failure (2014)
- Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial (2026)
Studied ranges, not dosing advice. Not medical advice — talk to a clinician. doseroutine.com/library/enalapril
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). Enalapril — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/enalapril
What compounds are similar to Enalapril?
Others in the medication category or studied for the same goals.
