Sources & methodology

• 476 compounds — supplements, vitamins and minerals, peptides, hormones including TRT, GLP-1 medications and common daily prescriptions.
• 308 interaction rules — a mix of named compound pairs and category-level rules that catch combinations without a specific pair entry.
• 1,957 indexed PubMed records attached to individual compounds and shown in the “Key studies” section of each library page.

• PubMed / NIH National Library of MedicinePeer-reviewed trials and reviews. Cited by PMID and linked to the original record.
• DailyMed (NIH)FDA-submitted prescribing information and product labeling for approved drugs.
• PubChemChemical identity, structure and basic pharmacology for each compound entry.
• NIH Office of Dietary SupplementsFact sheets for vitamins, minerals and dietary supplements.
• MedlinePlusPlain-language drug and supplement monographs used for consumer-facing wording.
• Cochrane LibrarySystematic reviews, used where a single trial would overstate the evidence.

We do not cite forums, vendor marketing pages, or unattributed blog posts. Where a claim's underlying source is unclear, the page shows no citation rather than a placeholder.

1. Mechanism first. A rule exists only when there is a plausible mechanism — shared metabolic pathway (for example CYP3A4), additive physiological effect, or absorption competition.
2. Evidence check. The mechanism is matched against literature and label warnings. Anecdote alone never creates a rule.
3. Severity assignment. Avoid, caution, note, or complementary — assigned from the strength of the evidence and the seriousness of the outcome, not from how common the combination is.
4. Plain-English write-up. Each rule states the mechanism and a practical recommendation (separate by hours, monitor, ask a clinician).
5. Attach references. Supporting documents are stored with the rule and rendered on the page and inside the interaction detail panel.

Compound and interaction entries are reviewed on a rolling cycle, and immediately when a reader reports a problem or when a label or systematic review changes. Pages that have been through an editorial review show a visible “Last reviewed” date near the top and publish the same date in their structured data.

Pages without that line have not yet completed a dated review pass — we leave the line off rather than showing a date we cannot stand behind.

DoseRoutine is educational reference content and a routine tracker. It is not medical advice, not a diagnosis, and not a substitute for your pharmacist or physician. Absence of an interaction rule is not proof that a combination is safe.

If something here is wrong, tell us and we will fix it. Our correction process, AI disclosure and review standards are documented in the editorial & review policy.