medicationPrescription only (US)FDA-approved and EMA-authorized for erectile dysfunction; prescription-only
VardenafilBenefits, Dosage & Interactions
Also known as: Levitra
Vardenafil is a medication primarily used for the treatment of erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase-5 (PDE5) inhibitors. It is typically taken pre workout. The reported plasma half-life is about 4 hours, which shapes dosing frequency.
How much Vardenafil do people take?
Studied and approved doses of 5 mg, 10 mg, and 20 mg film-coated tablets in the cited trials. Route reported: Oral tablet (an orally disintegrating formulation is also referenced in the label literature). Frequency reported: Taken as needed, roughly 25–60 minutes before sexual activity, no more than once daily. These are amounts documented in the cited studies and labels for Vardenafil — they are reported for reference, not a recommendation. Regulatory status differs by country, including between the US (FDA) and Canada (Health Canada). Confirm any amount with a licensed clinician before you take it.
See the full reported protocol and its sourcesResearched by DoseRoutine Research TeamReviewed for accuracy by Nicholas Alexander, RSE, SO, PMPLast updated Educational reference only — not medical advice. Always confirm dosing and safety decisions with a licensed clinician.
Evidence: Strong — 2 human randomized trials and regulatory approval on file.
Evidence strengthStrong · 4/4
PreclinicalStrong human evidence
2 human randomized trials and regulatory approval on file.
Plasma half-life
4–5 h
Typical timing
before training
Default unit
mg
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
- Reported amounts
- Studied and approved doses of 5 mg, 10 mg, and 20 mg film-coated tablets in the cited trials[1][2]
- Route studied
- Oral tablet (an orally disintegrating formulation is also referenced in the label literature)[1][2]
Reported for Vardenafil in the cited sources. Published ranges are not dosing advice.
References & evidence
Documents the Vardenafil entry is written from. Each number matches an inline marker above.
- [1]Vardenafil in the Treatment of Male Erectile Dysfunction: A Systematic Review and Meta-AnalysisWang H, Guo B, Huang Z, Zhao X, Ji Z · Advances in Therapy · 2021 · Peer-reviewed · PMID 33432539
- [2]Spotlight on vardenafil in erectile dysfunctionKeating GM, Scott LJ · Drugs & Aging · 2004 · Peer-reviewed · PMID 14960129
References & Evidence
Sources on this page that document Vardenafil dosing, timing and safety.
- [1]U.S. National Library of Medicine View source
- [2]National Center for Biotechnology Information View source
Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.
What is Vardenafil?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.
Vardenafil is a medication primarily used for the treatment of erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase-5 (PDE5) inhibitors. The drug works by increasing blood flow to the penis, which helps to achieve and maintain an erection suitable for sexual activity. Vardenafil is available in tablet form and is typically taken orally. While effective for many individuals, it requires sexual stimulation to work. It was initially marketed under the brand name Levitra. (FDA label, DrugBank)
What does the research say about Vardenafil?
Tap a section to expand.
Vardenafil's mechanism of action involves the selective inhibition of phosphodiesterase type 5 (PDE5), an enzyme found predominantly in the corpus cavernosum of the penis. During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP). cGMP causes the smooth muscles in the corpus cavernosum to relax, allowing for increased blood flow and subsequent erection. PDE5 breaks down cGMP, thus reducing its concentration. By inhibiting PDE5, vardenafil prolongs the action of cGMP, facilitating smooth muscle relaxation and enhanced blood flow in response to sexual stimulation. It's important to note that vardenafil does not directly cause an erection; sexual arousal is necessary for its effects to manifest. (FDA label, DrugBank)
Source for this section: Sources for How does Vardenafil work?: Jumps to this entry in the sources and references list at the end of the page.
The primary benefit of vardenafil is its effectiveness in treating erectile dysfunction. Clinical trials have consistently shown that vardenafil can significantly improve the ability of men with ED to achieve and maintain erections firm enough for sexual intercourse. This improvement can lead to enhanced sexual satisfaction and overall quality of life for individuals and their partners. Studies have demonstrated its efficacy across various causes of ED, including psychological, organic, and mixed etiologies. The onset of action can be relatively quick for some individuals, and its duration of effect allows for a window of opportunity for sexual activity. (Cochrane, FDA label)
Numerous randomized controlled trials and meta-analyses have evaluated the efficacy and safety of vardenafil for erectile dysfunction. A review published in Cochrane identified vardenafil as an effective treatment, demonstrating a statistically significant improvement in erectile function compared to placebo across diverse patient populations. Specific studies have shown successful penetration rates and improved scores on validated scales like the International Index of Erectile Function (IIEF). The improvements in erectile function typically translate into increased satisfaction with sexual intercourse, as reported by patients and partners. Evidence suggests that vardenafil is generally well-tolerated, with side effects consistent with the PDE5 inhibitor class. Efficacy has been documented in men with diabetes, prostatectomy, and other comorbidities often associated with ED. (Cochrane, FDA label)
Common side effects associated with vardenafil include headache, flushing (redness and warmth in the face), nasal congestion, dyspepsia (indigestion), and dizziness. Less common but reported side effects include nausea, back pain, and visual disturbances, such as blurred vision or a bluish tinge to vision. Rarely, more serious adverse events have been reported, such as priapism (a prolonged erection lasting more than four hours, which requires immediate medical attention) and sudden decrease or loss of vision or hearing. If any severe or persistent side effects occur, medical advice should be sought promptly. (FDA label, MedlinePlus)
Source for this section: Sources for What are the side effects of Vardenafil?: Jumps to this entry in the sources and references list at the end of the page.
Individuals with certain pre-existing conditions should exercise caution when using vardenafil. It should be used with caution in patients with cardiovascular disease, including those with unstable angina, recent myocardial infarction (heart attack), or stroke. A thorough cardiac evaluation is recommended before starting treatment. Individuals with conditions that predispose them to priapism, such as sickle cell anemia, multiple myeloma, or leukemia, should also use vardenafil with caution due to the increased risk of prolonged erections. Patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie's disease) are also at increased risk. Dosage adjustments may be necessary for patients with hepatic impairment or severe renal impairment. It is important to avoid driving or operating heavy machinery if dizziness or visual disturbances occur. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Source for this section: Sources for Who should avoid Vardenafil?: Jumps to this entry in the sources and references list at the end of the page.
Vardenafil is contraindicated in patients with a known hypersensitivity to the drug or any of its components. It is also strictly contraindicated in patients who are concurrently using nitrates in any form (e.g., nitroglycerin, isosorbide dinitrate), either regularly or intermittently, due to the risk of a sudden and significant drop in blood pressure. The co-administration of vardenafil with guanylate cyclase stimulators, such as riociguat, is also contraindicated due to the potential for severe hypotension. Individuals with severe cardiovascular disease for whom sexual activity is inadvisable should also not use vardenafil. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Source for this section: Sources for When should Vardenafil not be taken?: Jumps to this entry in the sources and references list at the end of the page.
Vardenafil should not be mixed with nitrates (e.g., nitroglycerin, isosorbide mononitrate/dinitrate) under any circumstances, as this combination can lead to a dangerous and potentially life-threatening drop in blood pressure. Co-administration with guanylate cyclase stimulators (e.g., riociguat) is also contraindicated due to similar hypotensive risks. Caution is advised when combining vardenafil with alpha-blockers; concurrent use can lead to symptomatic hypotension in some patients, especially when given within a short timeframe. Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, indinavir, erythromycin, clarithromycin) can significantly increase vardenafil exposure, necessitating a dose reduction of vardenafil. Grapefruit juice can also increase plasma concentrations of vardenafil and should be avoided or consumed with caution. Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil) may also require dose adjustments. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Source for this section: Sources for What should you not mix with Vardenafil?: Jumps to this entry in the sources and references list at the end of the page.
Vardenafil is typically taken orally approximately 60 minutes before sexual activity. It can be taken with or without food. However, consuming a high-fat meal immediately before taking vardenafil may delay the absorption and onset of action. The effects of vardenafil can last for several hours, with an average half-life of approximately 5 hours. Only one dose should be taken within a 24-hour period. Dose is user-directed and must be set by a licensed clinician. (FDA label, DrugBank)
Source for this section: Sources for When should you take Vardenafil?: Jumps to this entry in the sources and references list at the end of the page.
Put it into practice
Reading about Vardenafil is the first step — DoseRoutine helps you act on it. These free tools turn what you just learned into a routine.
What interacts with Vardenafil?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Any supplement + medication | Note | Category ruleConfidence: theoretical | Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist. |
| Any vitamin + medication | Note | Category ruleConfidence: theoretical | Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Specific pairs are checked against a licensed source; confirm with your provider. |
| Lisinopril | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
| Amlodipine | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
| Losartan | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
| Valsartan | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
| Enalapril | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
| Ramipril | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Start PDE5 at the lowest effective dose and monitor for hypotension. |
| Amantadine | Caution | Compound pairConfidence: theoretical | PDE5 inhibitors lower blood pressure; amantadine can add orthostatic hypotension.Source for this interaction: Jumps to this entry in the sources and references list at the end of the page. | Rise slowly; monitor BP. Report dizziness or fainting. |
Frequently asked questions about Vardenafil
Vardenafil is primarily used to treat erectile dysfunction (ED) in adult men by helping to increase blood flow to the penis during sexual arousal.
Vardenafil typically starts working within 30 to 60 minutes after being taken. For best results, it is usually recommended to take it about an hour before sexual activity.
Vardenafil can be taken with or without food. However, a high-fat meal might delay the absorption and onset of its effects.
Common side effects include headache, flushing, nasal congestion, indigestion, and dizziness. More serious side effects are rare but can occur.
Vardenafil, sildenafil (Viagra), and tadalafil (Cialis) are all PDE5 inhibitors used for ED, but they have different chemical structures, onset times, and durations of action. Your clinician can advise which may be most suitable for you.
Vardenafil is a medication, and interactions are possible with prescriptions, hormones, peptides and other supplements in the same routine. Because Vardenafil is usually taken before training, most avoidable conflicts come from what else lands in that same window. With a reported plasma half-life near 4 hours, separating doses can change the picture as much as removing one. Risk depends on dose, timing and what else is taken the same day, so each pairing has to be checked rather than assumed safe. The free checker at https://doseroutine.com/interaction-checker covers Vardenafil with no sign-up.
Vardenafil is typically taken before training. The reported plasma half-life is about 4 hours, which is what drives how often it is redosed. Ranges reported in the literature are not recommendations; use the dose your clinician or the product label gives you.
Combining a medication like Vardenafil with TRT is usually a question of labs rather than a blanket yes or no: the ester, injection interval and any aromatase inhibitor all change the answer. No general contraindication applies across every TRT protocol, so confirm the combination with the prescribing clinician. See the free TRT interaction reference: https://doseroutine.com/trt-supplement-interactions
Each peptide class carries its own profile against Vardenafil: a healing peptide raises different questions than a GLP-1 agonist or a growth-hormone secretagogue. Check the combination peptide by peptide rather than as one group, and review it with a clinician familiar with peptide protocols.
A short plasma half-life of roughly 4 hours is why protocols often split Vardenafil across the day rather than using a single dose. It is typically taken before training. Frequency is a clinical decision, not a fixed rule — confirm it with the prescriber or product label. Comparison of apps that keep a schedule like this: https://doseroutine.com/best-dose-tracking-apps
Because Vardenafil clears quickly (plasma half-life around 4 hours), a missed dose leaves a real gap in exposure rather than being buffered by what is still in your system. Doubling up to "catch up" is generally not appropriate unless the label or prescriber says so. Follow the missed-dose instructions on your label or from your clinician, and log the miss so the pattern is visible later rather than forgotten.
For Vardenafil the useful record is the dose, the time it was actually taken, and what else was taken in the same window. A written log or spreadsheet works for planning but does not remind you or flag conflicts — see the honest comparison at https://doseroutine.com/vs/spreadsheet and the wider roundup at https://doseroutine.com/best-dose-tracking-apps — DoseRoutine tracks the schedule, the remaining supply and interactions with the rest of your routine in one place.
Studied and approved doses of 5 mg, 10 mg, and 20 mg film-coated tablets in the cited trials. Route reported: Oral tablet (an orally disintegrating formulation is also referenced in the label literature). Frequency reported: Taken as needed, roughly 25–60 minutes before sexual activity, no more than once daily. These are amounts documented in the cited studies and labels for Vardenafil — they are reported for reference, not a recommendation. Regulatory status differs by country, including between the US (FDA) and Canada (Health Canada). Confirm any amount with a licensed clinician before you take it.
Which studies looked at Vardenafil?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Vardenafil(opens PubMed in a new tab)Expert Opin Investig Drugs · 2002 · PMID 12387708 · https://pubmed.ncbi.nlm.nih.gov/12387708/
- 2.Vardenafil(opens PubMed in a new tab)Drugs Aging · 2002 · PMID 12027779 · https://pubmed.ncbi.nlm.nih.gov/12027779/
Sources cited on this page
Specific documents referenced by the numbered markers above. Each number matches the marker in the text.
- MedlinePlus(opens in a new tab)U.S. National Library of Medicine · medlineplus.gov/druginfo/meds/a603035.html
- PubChem CID 135438569(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/135438569
Verify at
Publisher search links for Vardenafil. These are places to check the information — they are not citations, so they are not numbered.
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- Examine.com(publisher search, opens in a new tab)Examine.com · publisher search
- FDA-approved labeling (DailyMed)(publisher search, opens in a new tab)U.S. Food and Drug Administration · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- Wikipedia entry(publisher search, opens in a new tab)Wikipedia · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on Vardenafil?
Plain-text summary, safe to quote verbatim:
Vardenafil is a medication primarily used for the treatment of erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase-5 (PDE5) inhibitors. It is typically taken pre workout. The reported plasma half-life is about 4 hours, which shapes dosing frequency.
Source: DoseRoutine — https://doseroutine.com/library/vardenafil
Vardenafil cheat sheet
DoseRoutine cheat sheet · Medication
Vardenafil
Vardenafil is a medication primarily used for the treatment of erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase-5 (PDE5) inhibitors.
Evidence
Strong
2 human randomized trials and regulatory approval on file.
Studied range
Studied and approved doses of 5 mg, 10 mg, and 20 mg film-coated tablets in the cited trials
Route
Oral tablet (an orally disintegrating formulation is also referenced in the label literature)
Frequency studied
Taken as needed, roughly 25–60 minutes before sexual activity, no more than once daily
Half-life
4–5 h
Timing
before training
Prescription only (US)FDA-approved and EMA-authorized for erectile dysfunction; prescription-only
Studied ranges, not dosing advice. Not medical advice — talk to a clinician. doseroutine.com/library/vardenafil
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). Vardenafil — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/vardenafil
What compounds are similar to Vardenafil?
Others in the medication category or studied for the same goals.