Dehydroepiandrosterone (DHEA) is a steroid hormone naturally produced by the adrenal glands, gonads, and brain. It is the most abundant circulating steroid hormone in humans. DHEA serves as a precursor to other steroid hormones, including androgens (like testosterone) and estrogens (like estradiol). Levels of DHEA naturally peak in early adulthood and decline with age. Interest in DHEA as a supplement stems from its potential to counteract age-related declines in hormone levels and its widespread presence in the body. While DHEA is available as a dietary supplement in some countries, its classification can vary, and its use is subject to different regulations globally. (NIH ODS, DrugBank)
Deep dive
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Known interactions
Category rule: peptide × hormone
Note
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
Sources referenced
- NIH Office of Dietary Supplements (ODS)
- DrugBank
- PubChem
- Mayo Clinic
- MedlinePlus
- Cochrane Library
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