Hordenine (N,N-dimethyltyramine) is a naturally occurring alkaloid found in various plants, including barley (Hordeum vulgare), certain cacti, and some grasses, as well as in some foodstuffs. It is structurally related to tyramine and ephedrine. Historically, hordenine has been investigated for its potential effects on the nervous system and metabolism. In contemporary use, it is predominantly found in dietary supplements, particularly those marketed for athletic performance, weight management, and cognitive enhancement. While some traditional uses of hordenine-containing plants exist, the isolated compound's modern application is primarily within the supplement industry. (PubChem)
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Frequently asked
Sources referenced
["PubChem. Hordenine. National Library of Medicine.", "DrugBank. Hordenine.", "NIH Office of Dietary Supplements (ODS).", "MedlinePlus. National Library of Medicine.", "U.S. Food and Drug Administration (FDA)."]
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
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