
N-Acetyl L-TyrosineBenefits, Dosage & Interactions
Also known as: NALT
N-Acetyl L-Tyrosine (NALT) is an acetylated derivative of the amino acid L-tyrosine. L-tyrosine is a non-essential amino acid that serves as a precursor for several important neurotransmitters, including dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), collectively known as catecholamines. Research on N-Acetyl L-Tyrosine focuses on cognition and mood.
How much N-Acetyl L-Tyrosine do people take?
N-acetyl-L-tyrosine has been studied as a tyrosine substitute in parenteral nutrition formulas and in oral tyrosine-loading studies reviewed alongside free tyrosine doses of roughly 100–150 mg/kg body weight. Route reported: Intravenous in the parenteral-nutrition studies, oral in the reviewed tyrosine-supplementation literature. Frequency reported: Continuous infusion as part of daily parenteral nutrition, or single/repeated oral loading doses in the reviewed trials. These are amounts documented in the cited studies and labels for N-Acetyl L-Tyrosine — they are reported for reference, not a recommendation. Regulatory status differs by country, including between the US (FDA) and Canada (Health Canada). Confirm any amount with a licensed clinician before you take it.
See the full reported protocol and its sourcesResearched by DoseRoutine Research TeamReviewed for accuracy by Nicholas Alexander, RSE, SO, PMPLast updated Educational reference only — not medical advice. Always confirm dosing and safety decisions with a licensed clinician.
Covered by a systematic review, without regulatory approval.
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
- Reported amounts
- N-acetyl-L-tyrosine has been studied as a tyrosine substitute in parenteral nutrition formulas and in oral tyrosine-loading studies reviewed alongside free tyrosine doses of roughly 100–150 mg/kg body weight[1][2][3]
Reported for N-Acetyl L-Tyrosine in the cited sources. Published ranges are not dosing advice.
References & evidence
Documents the N-Acetyl L-Tyrosine entry is written from. Each number matches an inline marker above.
- [1]N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutritionBerlana D, Sabin P, Gimeno-Ballester V, et al. · JPEN. Journal of Parenteral and Enteral Nutrition · 2003 · Peer-reviewed · PMID 14621123
- [2]Utilization of tyrosine dipeptides and acetyltyrosine in normal and uremic humansFurst P, Stehle P · The American Journal of Physiology · 1991 · Peer-reviewed · PMID 1996632
- [3]Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A reviewJongkees BJ, Hommel B, Kuhn S, Colzato LS · Journal of Psychiatric Research · 2015 · Peer-reviewed · PMID 26424423
References & Evidence
Sources on this page that document N-Acetyl L-Tyrosine dosing, timing and safety.
- [1]National Center for Biotechnology Information View source
Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.
What is N-Acetyl L-Tyrosine studied for?
What is N-Acetyl L-Tyrosine?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.
What does the research say about N-Acetyl L-Tyrosine?
Tap a section to expand.
Source for this section: Sources for How does N-Acetyl L-Tyrosine work?: Jumps to this entry in the sources and references list at the end of the page.
Source for this section: Sources for When should you take N-Acetyl L-Tyrosine?: Jumps to this entry in the sources and references list at the end of the page.
Put it into practice
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What interacts with N-Acetyl L-Tyrosine?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Any glp1 + supplement | Note | Category ruleConfidence: theoretical | GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.Source pending | Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider. |
| Any supplement + medication | Note | Category ruleConfidence: theoretical | Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).Source pending | Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist. |
Frequently asked questions about N-Acetyl L-Tyrosine
Which studies looked at N-Acetyl L-Tyrosine?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Utilization of tyrosine-containing dipeptides and N-acetyl-tyrosine in hepatic failure(opens PubMed in a new tab)Hepatology · 1995 · PMID 7705801 · https://pubmed.ncbi.nlm.nih.gov/7705801/
- 2.Amino acid solutions for premature neonates during the first week of life: the role of N-acetyl-L-cysteine and N-acetyl-L-tyrosine(opens PubMed in a new tab)JPEN J Parenter Enteral Nutr · 1994 · PMID 7815670 · https://pubmed.ncbi.nlm.nih.gov/7815670/
Sources cited on this page
Specific documents referenced by the numbered markers above. Each number matches the marker in the text.
- PubChem CID 68310(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/68310
Verify at
Publisher search links for N-Acetyl L-Tyrosine. These are places to check the information — they are not citations, so they are not numbered.
- Examine.com(publisher search, opens in a new tab)Examine.com · publisher search
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- DailyMed labeling archive(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- Wikipedia entry(publisher search, opens in a new tab)Wikipedia · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on N-Acetyl L-Tyrosine?
Plain-text summary, safe to quote verbatim:
N-Acetyl L-Tyrosine (NALT) is an acetylated derivative of the amino acid L-tyrosine. L-tyrosine is a non-essential amino acid that serves as a precursor for several important neurotransmitters, including dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), collectively known as catecholamines. Research on N-Acetyl L-Tyrosine focuses on cognition and mood.
N-Acetyl L-Tyrosine cheat sheet
DoseRoutine cheat sheet · Supplement
N-Acetyl L-Tyrosine
N-Acetyl L-Tyrosine (NALT) is an acetylated derivative of the amino acid L-tyrosine. L-tyrosine is a non-essential amino acid that serves as a precursor for several important neurotransmitters, including dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), collectively known as catecholamines.
Evidence
Moderate
Covered by a systematic review, without regulatory approval.
Studied range
N-acetyl-L-tyrosine has been studied as a tyrosine substitute in parenteral nutrition formulas and in oral tyrosine-loading studies reviewed alongside free tyrosine doses of roughly 100–150 mg/kg body weight
Route
Intravenous in the parenteral-nutrition studies, oral in the reviewed tyrosine-supplementation literature
Frequency studied
Continuous infusion as part of daily parenteral nutrition, or single/repeated oral loading doses in the reviewed trials
Timing
in the morning
With food
on an empty stomach
Key references
Studied ranges, not dosing advice. Not medical advice — talk to a clinician. doseroutine.com/library/n-acetyl-l-tyrosine
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). N-Acetyl L-Tyrosine — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/n-acetyl-l-tyrosine
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