mineralNot FDA-approvedOTC supplementSold in the US as an unregulated dietary supplement, not an FDA-approved drugTolerable upper intake level for adults is 40 mg/day of elemental zinc from all sources combined
Zinc BisglycinateBenefits, Dosage & Interactions
Zinc bisglycinate (zinc chelated to two glycine molecules) is a supplemental form of zinc chosen for absorption and tolerability. Research on Zinc Bisglycinate focuses on immune function, tissue recovery, and cognition and mood. It is typically taken with a meal.
Researched by DoseRoutine R&D TeamReviewed for accuracy by Nicholas Alexander, RSELast updated
Evidence: Strong — 2 human randomized trials published.
Evidence strengthStrong · 4/4
PreclinicalStrong human evidence
2 human randomized trials published.
Quick answer
Zinc bisglycinate (zinc chelated to two glycine molecules) is a supplemental form of zinc chosen for absorption and tolerability. Chelation lets it bypass some of the competition and phytate binding that limits ionic salts like zinc oxide, and comparison studies generally show higher plasma zinc responses and less nausea than oxide or sulfate. The adult RDA is 8–11 mg of elemental zinc daily, and the tolerable upper intake level is 40 mg from all sources combined.
- Form
- Zinc chelated to two glycine molecules (bisglycinate)
- Why it is used
- Higher absorption and less stomach upset than zinc oxide
- Adult RDA
- 8 mg/day for women, 11 mg/day for men (elemental zinc)
- Upper limit
- 40 mg/day elemental zinc from all sources (US UL)
- Best taken
- With food if nausea occurs; away from high-phytate meals
- Key interactions
- Copper, iron, calcium, tetracycline and quinolone antibiotics
Compiled by DoseRoutine from public sources including NIH/MedlinePlus, the FDA label, Mayo Clinic and PubChem. Educational information, not medical advice.
Whole-body biological half-life
Not applicable
Typical timing
with meal
Food rule
with food
Default unit
mg
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
- Reported amounts
- Human trials of zinc glycinate (zinc bisglycinate) used doses of 15 mg elemental zinc per day in children and 60 mg elemental zinc per day in the adult-women comparison study; the narrative review covers a broader range of studied chemical forms[1][2][3]
- Cycle length
- 6 weeks in the adult plasma-zinc comparison; 3 months in the pediatric cold-prevention trial[1][2][3]
Reported for Zinc Bisglycinate in the cited sources. Published ranges are not dosing advice.
References & evidence
Documents the Zinc Bisglycinate entry is written from. Each number matches an inline marker above.
- [1]Comparative Absorption and Bioavailability of Various Chemical Forms of Zinc in Humans: A Narrative ReviewDevarshi PP, Mao Q, Grant RW, Hazels Mitmesser S · Nutrients · 2024 · Peer-reviewed · PMID 39770891
- [2]Moderately High Dose Zinc Gluconate or Zinc Glycinate: Effects on Plasma Zinc and Erythrocyte Superoxide Dismutase Activities in Young Adult WomenDiSilvestro RA, Koch E, Rakes L · Biological Trace Element Research · 2015 · Peer-reviewed · PMID 25877802
- [3]A randomized controlled trial of chelated zinc for prevention of the common cold in Thai school childrenRerksuppaphol S, Rerksuppaphol L · Paediatrics and International Child Health · 2013 · Peer-reviewed · PMID 23930726
How to track Zinc Bisglycinate doses
Tracking Zinc Bisglycinate well takes four fields and a habit. Here is what to record so the log is still useful in three months.
- 1
Add the dose and unit
Log Zinc Bisglycinate with its dose in mg so totals stay comparable over time — including days when you split the dose or skip it.
- 2
Set the time of day and food rule
Typical timing is with_meal. Take it with food, and record it that way so absorption stays consistent. Reminders fire at that time and can export to your calendar.
- 3
Check it against the rest of the stack
Run Zinc Bisglycinate through the interaction checker against everything else in the routine — supplements, peptides, hormones and prescriptions — before it becomes a daily habit.
- 4
Log adherence, not intentions
Mark each dose taken, skipped or delayed as it happens. Weeks of honest logs are what make an adherence rate or a trend line meaningful; retrospective guessing is not.
- 5
Review against outcomes
Review Zinc Bisglycinate alongside your logged metrics and any relevant blood work every few weeks before changing the dose, so the change is a response to data rather than to a good or bad day.
What to log each time
- Dose in mg
- Time of day and whether it was taken with food
- Taken / skipped / delayed
- Any side effects or notable changes
References & Evidence
Sources on this page that document Zinc Bisglycinate dosing, timing and safety.
- [1]National Center for Biotechnology Information View source
Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.
What is Zinc Bisglycinate studied for?
What is Zinc Bisglycinate?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.
Zinc bisglycinate is a chelated form of the essential trace mineral zinc, where zinc ions are bound to two molecules of the amino acid glycine. This chelation process is designed to enhance the absorption and bioavailability of zinc in the body compared to other forms, such as zinc oxide or zinc gluconate (PubChem). As an essential mineral, zinc plays a crucial role in numerous physiological processes, including immune function, cell division, wound healing, protein synthesis, and DNA synthesis (National Institutes of Health Office of Dietary Supplements). It is a cofactor for over 300 enzymes involved in metabolic reactions. Dietary sources of zinc include red meat, poultry, seafood (especially oysters), dairy products, nuts, legumes, and whole grains. Despite its presence in various foods, zinc deficiency can occur, particularly in individuals with certain dietary restrictions (e.g., vegetarians, vegans), gastrointestinal disorders, or those with increased needs, such as pregnant women and children (MedlinePlus). Zinc bisglycinate is commonly used as a dietary supplement to address or prevent zinc deficiency and to support overall health.
What does the research say about Zinc Bisglycinate?
Tap a section to expand.
The primary mechanism of action for zinc bisglycinate revolves around its role as an essential nutrient. Once ingested, the chelated structure of zinc bisglycinate is thought to protect the zinc ion from binding to dietary inhibitors in the gastrointestinal tract, such as phytates found in grains and legumes (PubChem). This protection allows the zinc to be more readily absorbed across the intestinal wall. Glycine, the chelating agent, is a small amino acid that is easily absorbed, and it is hypothesized that the zinc-glycine complex is transported into intestinal cells via amino acid transporters, rather than relying solely on metallic ion transporters (Examine.com). Once absorbed, zinc becomes available for its diverse biological functions. It acts as a cofactor for hundreds of enzymes, facilitating various biochemical reactions. These include enzymes involved in:
* **Immune response:** Zinc is critical for the development and function of immune cells, including T-lymphocytes and natural killer cells. It helps regulate immune signaling and reduce oxidative stress, supporting both innate and adaptive immunity (National Institutes of Health Office of Dietary Supplements).
* **Cell growth and division:** Zinc is essential for DNA and RNA synthesis, vital for cell proliferation and repair. This is particularly important for rapidly dividing cells, such as those in the immune system and gastrointestinal lining.
* **Protein synthesis:** As a component of numerous metalloenzymes, zinc is involved in the synthesis of proteins, which are fundamental for all bodily structures and functions.
* **Wound healing:** Zinc supports collagen synthesis and epithelial regeneration, processes crucial for effective wound repair.
* **Antioxidant defense:** Zinc is a component of superoxide dismutase (SOD), an important antioxidant enzyme that helps protect cells from damage caused by free radicals.
* **Sensory function:** It plays a role in taste perception and vision.
By providing a readily available and efficiently absorbed source of zinc, zinc bisglycinate supports these vital functions, contributing to overall health and preventing deficiencies.
Source for this section: Sources for How does Zinc Bisglycinate work?: Jumps to this entry in the sources and references list at the end of the page.
The benefits of zinc bisglycinate largely stem from its ability to effectively deliver zinc to the body, thereby supporting the numerous physiological roles of this essential mineral. Research and clinical observations suggest several key areas where adequate zinc status, often supported by supplementation with bioavailable forms like bisglycinate, can be beneficial:
* **Immune System Support:** Zinc is well-established for its critical role in immune function (Mayo Clinic). Adequate zinc levels are necessary for the development and proper functioning of immune cells, including T-lymphocytes and natural killer cells. Supplementation has been studied for its potential to reduce the duration and severity of common colds when taken at the onset of symptoms, and to support immune function in vulnerable populations (Cochrane Review).
* **Skin Health and Wound Healing:** Zinc is vital for cell proliferation, collagen synthesis, and immune response, all of which are crucial for skin integrity and wound repair (MedlinePlus). It has been studied in the context of various skin conditions, including acne, due to its anti-inflammatory and antibacterial properties and its role in regulating oil gland function (PubChem).
* **Antioxidant Protection:** Zinc functions as an antioxidant, playing a role in protecting cells from oxidative damage caused by free radicals. It is a component of superoxide dismutase (SOD), an important enzyme in the body's antioxidant defense system (National Institutes of Health Office of Dietary Supplements).
* **Cognitive Function:** While direct evidence for zinc bisglycinate specifically impacting cognition is emerging, general zinc status is linked to neurodevelopment and cognitive function. Zinc's role in neurotransmitter function and neuronal signaling suggests its importance for brain health.
* **Reproductive Health:** Zinc is essential for reproductive health in both men and women. In males, it supports sperm production and testosterone metabolism. In females, it plays a role in ovarian function and early embryonic development (National Institutes of Health Office of Dietary Supplements).
* **Nutritional Support for Deficiency:** For individuals at risk of or experiencing zinc deficiency, supplementation with a highly absorbable form like zinc bisglycinate can help restore optimal zinc levels and alleviate deficiency-related symptoms, such as impaired immune function, poor wound healing, and growth retardation in children (MedlinePlus).
* **Enhanced Absorption:** A key benefit of zinc bisglycinate specifically is its superior absorption rate compared to other forms of zinc. This means that a potentially lower dose might achieve similar physiological effects, and it may be better tolerated by individuals who experience gastrointestinal upset with other zinc supplements (Examine.com).
Evidence regarding zinc bisglycinate specifically often focuses on its enhanced bioavailability compared to other zinc forms. Human studies comparing the absorption of zinc bisglycinate to zinc gluconate or zinc oxide have shown that zinc bisglycinate is absorbed more efficiently. For instance, a study published in the 'Journal of Nutrition' evaluated zinc absorption in human subjects and found that zinc from amino acid chelates, including bisglycinate, had significantly higher bioavailability compared to inorganic zinc salts (Examine.com). This improved absorption means that generally a smaller dose of zinc bisglycinate may be needed to achieve similar physiological effects or to correct a deficiency, potentially reducing the risk of gastrointestinal side effects sometimes associated with higher doses of less absorbable forms (PubChem).
Broader clinical evidence for the benefits of zinc, irrespective of the form, strongly supports its role in:
* **Immune Modulation:** A comprehensive Cochrane review analyzed numerous randomized controlled trials on zinc supplementation for the common cold. It concluded that zinc, when taken within 24 hours of symptom onset, can reduce the duration and severity of the common cold in healthy people. This effect is attributed to zinc's role in immune cell function and anti-inflammatory properties (Cochrane Review).
* **Wound Healing:** Studies have shown that topical and oral zinc supplementation can aid in wound healing, particularly in individuals with zinc deficiency or those with chronic wounds. Zinc's involvement in collagen synthesis, epithelialization, and immune response makes it crucial for tissue repair (MedlinePlus).
* **Management of Diarrhea:** The World Health Organization (WHO) and UNICEF recommend zinc supplementation for children with acute diarrhea to reduce the severity and duration of the episode and to prevent future occurrences, especially in regions with high prevalence of zinc deficiency (National Institutes of Health Office of Dietary Supplements).
* **Nutritional Deficiency Correction:** The efficacy of zinc supplementation in correcting zinc deficiency and its associated symptoms (e.g., growth retardation, impaired immune function, taste disturbances) is well-documented by reputable health organizations like the National Institutes of Health Office of Dietary Supplements. Zinc bisglycinate, due to its high bioavailability, is an effective choice for this purpose (Mayo Clinic).
While zinc bisglycinate is a popular choice for supplementation due to its absorption profile, the majority of the clinical outcomes described above are attributed to zinc itself, rather than being exclusive to the bisglycinate form. However, the form's superior absorption enhances the likelihood of achieving these benefits by ensuring adequate zinc delivery to the body.
While generally well-tolerated, particularly due to its enhanced absorption, zinc bisglycinate can still cause side effects, especially at higher doses or in sensitive individuals. Common side effects often relate to the digestive system and may include:
* Nausea
* Vomiting
* Diarrhea
* Abdominal cramps or pain
Less common or more severe side effects, usually associated with long-term high-dose zinc intake (which can be exacerbated by poor absorption of other forms but can still occur with bisglycinate), may include:
* Copper deficiency, as zinc competes with copper for absorption, potentially leading to anemia and neurological problems.
* Suppression of immune function at very high chronic doses, counterintuitive to its immune-supportive role at appropriate levels.
* Altered cholesterol levels, specifically lowered HDL ('good') cholesterol.
If you experience any adverse reactions, discontinue use and consult a healthcare professional. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Zinc supplementation requires careful consideration. Individuals with known allergies or hypersensitivity to zinc or any components of the supplement should avoid its use. While zinc bisglycinate is generally well-absorbed and may mitigate some gastrointestinal issues associated with other forms of zinc, adverse effects can still occur, especially if taken in excessive amounts. Prolonged high-dose zinc intake can lead to copper deficiency, which can manifest as neurological problems (e.g., numbness, weakness) and anemia, due to zinc's interference with copper absorption. It can also suppress immune function over time, rather than supporting it. People with pre-existing medical conditions, particularly kidney disease (as zinc is excreted by the kidneys) or conditions affecting mineral balance, should consult a healthcare provider before using zinc supplements. Pregnant and breastfeeding individuals should only use zinc supplements under the guidance of a clinician, as excessive intake can be harmful (Mayo Clinic). Always adhere to recommended intake levels and consider total zinc intake from diet and other supplements. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Contraindications for zinc bisglycinate are primarily related to underlying medical conditions or specific physiological states where zinc supplementation, or any form of zinc, could be detrimental. Absolute contraindications are rare, but caution is advised in the following situations:
* **Known Hypersensitivity:** Individuals with a confirmed allergy or severe adverse reaction to zinc or any component of the supplement should avoid its use.
* **Severe Copper Deficiency:** In cases of diagnosed copper deficiency, zinc supplementation is generally contraindicated unless carefully managed by a clinician, as zinc can further impair copper absorption and worsen the deficiency (MedlinePlus).
* **Certain Genetic Disorders:** Rare genetic disorders affecting mineral metabolism, such as idiopathic copper toxicosis (Wilson's disease, although zinc is sometimes used as a treatment, it must be clinician-directed) or conditions impacting zinc transporters, may warrant caution or specific forms of zinc therapy.
Relative contraindications or situations requiring extreme caution and medical supervision include severe kidney disease, as zinc elimination can be affected. Individuals undergoing certain cancer treatments may also need to discuss zinc supplementation with their oncology team. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Zinc bisglycinate can interact with various medications and other supplements, potentially altering their effectiveness or increasing the risk of adverse effects. It is important to be aware of these potential interactions:
* **Antibiotics:** Zinc can interfere with the absorption of certain antibiotics, including quinolones (e.g., ciprofloxacin, levofloxacin) and tetracyclines (e.g., doxycycline). To minimize this interaction, zinc bisglycinate should be taken at least 2 hours before or 4-6 hours after these antibiotics (National Institutes of Health Office of Dietary Supplements).
* **Chelating Agents:** Medications used to reduce heavy metal levels in the body (e.g., penicillamine, trientine) can bind to zinc, reducing its absorption and effectiveness. Conversely, zinc might also affect the action of these drugs.
* **Diuretics:** Thiazide diuretics (e.g., hydrochlorothiazide) can increase zinc excretion, potentially leading to lower zinc levels in the body.
* **Other Mineral Supplements:** High doses of zinc can compete with other essential minerals like copper and iron for absorption in the gut. Long-term, high-dose zinc supplementation can lead to copper deficiency. It's advisable to take zinc and iron supplements at separate times or to ensure balanced intake of all essential minerals (Mayo Clinic).
* **NSAIDs (Nonsteroidal Anti-inflammatory Drugs):** Some evidence suggests that prolonged use of NSAIDs might affect zinc status, although the interaction with zinc supplements is less clear, caution is advised.
Always inform your healthcare provider about all supplements and medications you are taking to identify potential interactions. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Zinc bisglycinate is typically taken with food ('with_meal') to enhance absorption and minimize the potential for gastrointestinal upset, such as nausea or stomach upset, which can occur when zinc is taken on an empty stomach (PubChem). The presence of food can help buffer the zinc and facilitate its transport. While specific timing of day is generally not critical, consistency is often recommended for optimal results. If specific dietary factors interact with zinc (e.g., phytates in grains, which are less of a concern with chelated forms but can still be relevant with very high intake), taking it separately from meals particularly rich in these may sometimes be considered, though with bisglycinate it is less critical. Individual needs vary, and some individuals may find specific timing works best for them; consult a licensed clinician for personalized guidance.
Source for this section: Sources for When should you take Zinc Bisglycinate?: Jumps to this entry in the sources and references list at the end of the page.
What interacts with Zinc Bisglycinate?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Levothyroxine | Caution | Compound pairConfidence: theoretical | Divalent cations chelate levothyroxine in the gut and reduce absorption by up to 30%.Source pending | Take levothyroxine on empty stomach; separate mineral supplements by at least 4 hours.Suggested separation: 4 h |
Frequently asked questions about Zinc Bisglycinate
Zinc bisglycinate is a chelated form where zinc is bound to two glycine molecules. This chelation improves its absorption and bioavailability compared to inorganic forms like zinc oxide or zinc sulfate, and often results in less gastrointestinal upset. Studies show it is more effectively absorbed and utilized by the body (Examine.com).
Yes, zinc is crucial for immune system function. Adequate zinc levels support immune cell development and activity. Supplementation, including with zinc bisglycinate, can contribute to healthy immune responses and has been studied for its role in reducing the duration of common colds (National Institutes of Health Office of Dietary Supplements).
Zinc bisglycinate is typically best taken with food. Taking it with a meal can help reduce the likelihood of stomach upset and may further aid its efficient absorption (PubChem).
While generally well-tolerated, potential side effects can include nausea, vomiting, diarrhea, and stomach cramps, especially at higher doses. Long-term high-dose intake can also lead to copper deficiency and impact immune function or cholesterol levels (MedlinePlus).
Individuals with known allergies to zinc, those with severe copper deficiency, or certain rare genetic disorders affecting mineral metabolism should avoid it. People with kidney disease, those on specific medications (e.g., certain antibiotics, chelating agents), and pregnant/breastfeeding individuals should consult a clinician before use (Mayo Clinic).
Zinc Bisglycinate is a mineral, and interactions are possible with prescriptions, hormones, peptides and other supplements in the same routine. Because Zinc Bisglycinate is usually taken with a meal, most avoidable conflicts come from what else lands in that same window. Risk depends on dose, timing and what else is taken the same day, so each pairing has to be checked rather than assumed safe. The free checker at https://doseroutine.com/interaction-checker covers Zinc Bisglycinate with no sign-up.
Zinc Bisglycinate is typically taken with a meal. Published protocols usually have it taken with food. Ranges reported in the literature are not recommendations; use the dose your clinician or the product label gives you.
Combining a mineral like Zinc Bisglycinate with TRT is usually a question of labs rather than a blanket yes or no: the ester, injection interval and any aromatase inhibitor all change the answer. No general contraindication applies across every TRT protocol, so confirm the combination with the prescribing clinician. See the free TRT interaction reference: https://doseroutine.com/trt-supplement-interactions
Each peptide class carries its own profile against Zinc Bisglycinate: a healing peptide raises different questions than a GLP-1 agonist or a growth-hormone secretagogue. Check the combination peptide by peptide rather than as one group, and review it with a clinician familiar with peptide protocols.
Published frequency for Zinc Bisglycinate varies by protocol and formulation, so the label or prescription is what sets it. It is typically taken with a meal. Most protocols have it taken with food. Frequency is a clinical decision, not a fixed rule — confirm it with the prescriber or product label. Comparison of apps that keep a schedule like this: https://doseroutine.com/best-dose-tracking-apps
The effect of a missed dose of Zinc Bisglycinate depends on the protocol and formulation you are on. Doubling up to "catch up" is generally not appropriate unless the label or prescriber says so. Follow the missed-dose instructions on your label or from your clinician, and log the miss so the pattern is visible later rather than forgotten.
For Zinc Bisglycinate the useful record is the dose, the time it was actually taken, and what else was taken in the same window. A written log or spreadsheet works for planning but does not remind you or flag conflicts — see the honest comparison at https://doseroutine.com/vs/spreadsheet and the wider roundup at https://doseroutine.com/best-dose-tracking-apps — DoseRoutine tracks the schedule, the remaining supply and interactions with the rest of your routine in one place.
Zinc oxide is the clear laggard — it is poorly soluble and absorbs least. Bisglycinate and picolinate both outperform it in comparison studies, and bisglycinate has additional data showing higher plasma zinc and better tolerability than sulfate. Head-to-head evidence between bisglycinate and picolinate is thin, so the practical difference between those two is small. This is educational information, not medical advice.
Safety limits are set on elemental zinc, not on the total weight of the chelate, so check the elemental figure on the label. The US tolerable upper intake level is 40 mg of elemental zinc a day from all sources; sustained intake above that risks copper deficiency, anemia and impaired immune function. This is educational information, not medical advice.
At intakes near the RDA it does not. Chronic supplementation well above the RDA does interfere with copper absorption, which is why long-term high-dose regimens are often paired with about 1 mg of copper per 15 mg of zinc. That pairing is a hedge against a real depletion risk, not a benefit in itself. This is educational information, not medical advice.
Which studies looked at Zinc Bisglycinate?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Efficacy of zinc supplementation in the management of acute diarrhoea: a randomised controlled trial(opens PubMed in a new tab)Paediatr Int Child Health · 2020 · PMID 31578136 · https://pubmed.ncbi.nlm.nih.gov/31578136/
Sources cited on this page
Specific documents referenced by the numbered markers above. Each number matches the marker in the text.
- PubChem CID 151910(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/151910
Verify at
Publisher search links for Zinc Bisglycinate. These are places to check the information — they are not citations, so they are not numbered.
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- Examine.com(publisher search, opens in a new tab)Examine.com · publisher search
- Mayo Clinic(publisher search, opens in a new tab)Mayo Clinic · publisher search
- MedlinePlus(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- NIH Office of Dietary Supplements(publisher search, opens in a new tab)National Institutes of Health · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- DailyMed labeling archive(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- Wikipedia entry(publisher search, opens in a new tab)Wikipedia · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on Zinc Bisglycinate?
Plain-text summary, safe to quote verbatim:
Zinc bisglycinate (zinc chelated to two glycine molecules) is a supplemental form of zinc chosen for absorption and tolerability. Research on Zinc Bisglycinate focuses on immune function, tissue recovery, and cognition and mood. It is typically taken with a meal.
Source: DoseRoutine — https://doseroutine.com/library/zinc-bisglycinate
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). Zinc Bisglycinate — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/zinc-bisglycinate
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