supplementNot FDA-approvedOTC supplementSold in the US as a dietary supplement ingredient (branded as Setria by Kyowa Hakko); not FDA-approved as a drug and not evaluated by FDA for safety or efficacy claims
Setria GlutathioneBenefits, Dosage & Interactions
Setria Glutathione is a patented form of glutathione, a tripeptide composed of three amino acids: L-cysteine, L-glutamic acid, and glycine. Research on Setria Glutathione focuses on immune function. It is typically taken in the morning. Dose, response, and interaction risk vary by individual, so use should be reviewed with a clinician.
How much Setria Glutathione do people take?
Oral doses studied ranged from roughly 500 mg to 1,000 mg per day of reduced glutathione (as the Setria ingredient or comparable oral glutathione) in the cited crossover and combined-supplement trials. Route reported: Oral capsule or powder. Frequency reported: Once daily, or split doses, across trial durations of days to eight weeks. These are amounts documented in the cited studies and labels for Setria Glutathione — they are reported for reference, not a recommendation. Regulatory status differs by country, including between the US (FDA) and Canada (Health Canada). Confirm any amount with a licensed clinician before you take it.
See the full reported protocol and its sourcesResearched by DoseRoutine Research TeamReviewed for accuracy by Nicholas Alexander, RSE, SO, PMPLast updated Educational reference only — not medical advice. Always confirm dosing and safety decisions with a licensed clinician.
Evidence: Strong — 3 human randomized trials published.
Evidence strengthStrong · 4/4
PreclinicalStrong human evidence
3 human randomized trials published.
Plasma half-life
Not applicable
Typical timing
in the morning
Default unit
mg
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
- Reported amounts
- Oral doses studied ranged from roughly 500 mg to 1,000 mg per day of reduced glutathione (as the Setria ingredient or comparable oral glutathione) in the cited crossover and combined-supplement trials[1][2][3]
Reported for Setria Glutathione in the cited sources. Published ranges are not dosing advice.
References & evidence
Documents the Setria Glutathione entry is written from. Each number matches an inline marker above.
- [1]A Targeted Metabolomic Assessment of Oral Glutathione Bioavailability and Safety in Humans: A Randomized Crossover Clinical TrialSolnier J, Du M, Zhang Y, Roh YS · Antioxidants (Basel) · 2026 · Peer-reviewed · PMID 41897500
- [2]The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained malesCabre HE, Greenwalt CE, Gould LM, Smith-Ryan AE · Journal of the International Society of Sports Nutrition · 2023 · Peer-reviewed · PMID 37125500
- [3]Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postmenopausal WomenFigueroa A, Maharaj A, Kang Y, Dillon KN · Nutrients · 2023 · Peer-reviewed · PMID 37049398
What is Setria Glutathione studied for?
What is Setria Glutathione?
Setria Glutathione is a patented form of glutathione, a tripeptide composed of three amino acids: L-cysteine, L-glutamic acid, and glycine. Glutathione is naturally produced in the human body and plays a critical role in various physiological processes, including antioxidant defense, detoxification, and immune function. It is often referred to as the 'master antioxidant' due to its ability to neutralize free radicals and regenerate other antioxidants, such as vitamins C and E (PubChem, NIH ODS). Setria Glutathione is specifically designed for oral bioavailability, meaning it is formulated to be absorbed and utilized by the body when taken by mouth (Manufacturer's information). Endogenous glutathione levels can be influenced by diet, age, environmental toxins, and certain medical conditions. As a supplement, Setria Glutathione aims to support and maintain healthy glutathione levels in the body.
What does the research say about Setria Glutathione?
Tap a section to expand.
Glutathione's primary mechanism of action involves its sulfhydryl (SH) group, which is highly reactive and readily participates in redox reactions. It acts as a coenzyme for several detoxification enzymes, including glutathione S-transferases (GSTs), which catalyze the conjugation of toxic compounds with glutathione, making them more water-soluble and easier to excrete from the body (NIH ODS, PubChem). Beyond detoxification, glutathione directly neutralizes reactive oxygen species (ROS) and reactive nitrogen species (RNS) through direct conjugation or by acting as a substrate for glutathione peroxidase, an enzyme that converts hydrogen peroxide to water (NIH ODS). Glutathione also plays a crucial role in maintaining the redox state of cellular proteins, thereby protecting them from oxidative damage. Furthermore, it is involved in immune modulation by supporting the function of T-lymphocytes and other immune cells (Examine.com). Setria Glutathione, as an oral supplement, aims to increase circulating and intracellular glutathione levels, thereby supporting these vital cellular protective and detoxification pathways.
Research into the potential benefits of glutathione supplementation, including forms like Setria, often focuses on its roles in antioxidant defense and detoxification. Potential areas of interest include:
* **Antioxidant Support:** By directly neutralizing free radicals and regenerating other antioxidants, glutathione contributes to the body's overall antioxidant capacity, which may help protect cells from oxidative stress (PubChem, NIH ODS).
* **Detoxification:** Glutathione is integral to the Phase II detoxification pathway in the liver and other organs, facilitating the elimination of various toxins, environmental pollutants, and metabolic waste products (NIH ODS).
* **Immune System Modulation:** Adequate glutathione levels are thought to be important for optimal immune function, particularly for the activity of certain immune cells (Examine.com).
* **Cellular Health:** Through its multifaceted roles in reducing oxidative stress and supporting detoxification, glutathione is considered important for maintaining general cellular health and integrity (PubChem).
While these are areas of scientific interest, the extent to which oral glutathione supplementation consistently translates into significant clinical benefits across all individuals is an ongoing area of research. Individual responses can vary.
The evidence supporting the benefits of glutathione, including specifically Setria Glutathione, largely stems from studies investigating its role in maintaining cellular redox balance, detoxification, and immune function. Many studies have utilized various forms of glutathione or precursors to assess their impact on markers of oxidative stress and overall health.
* **Oral Bioavailability:** Studies on Setria Glutathione have focused on its absorption and ability to increase glutathione levels in the body following oral administration. Some research suggests that this specific form demonstrates improved bioavailability compared to conventional glutathione supplements (Manufacturer's information), though the magnitude and clinical significance of this improvement can be subject to ongoing investigation.
* **Oxidative Stress Markers:** Research has explored the effects of glutathione supplementation on markers of oxidative stress in various populations, with some studies indicating a reduction in oxidized cellular components (Cochrane Library reviews on antioxidants often include glutathione in their scope).
* **Immune Function:** Limited human studies exist on glutathione supplementation's direct impact on immune response, but in vitro and animal models suggest a role in immune cell function (Examine.com).
It is important to note that while laboratory and animal studies often highlight the crucial roles of glutathione, human clinical trials, particularly with specific supplemental forms like Setria, are continuously expanding. The full range of clinical applications and efficacy for various health outcomes is still being established through rigorous scientific inquiry (NIH ODS, Examine.com).
Glutathione is generally well-tolerated when taken orally. However, some individuals may experience mild side effects, particularly at higher doses or with prolonged use. These can include:
* Gastrointestinal upset, such as abdominal cramps or bloating.
* Allergic reactions, though rare, such as rash or difficulty breathing.
* Some reports indicate a potential for increased asthma symptoms in individuals with existing asthma, though this is not consistently observed across all studies.
Any unexpected or severe symptoms should prompt discontinuation of use and consultation with a healthcare professional. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Individuals considering glutathione supplementation, including Setria, should be aware of certain warnings. Pregnant or breastfeeding individuals should exercise caution and consult their healthcare provider before use, as there is insufficient reliable information on its safety in these populations. People with asthma should use glutathione with caution, as there have been anecdotal reports or limited studies suggesting it might exacerbate asthma symptoms in some sensitive individuals (MedlinePlus). Those with a known allergy to any component of the supplement should avoid its use. Furthermore, because glutathione plays a role in various metabolic pathways, its use in individuals with certain chronic conditions or those on specific medications should be discussed with a healthcare provider. Always adhere to the recommended intake and cease use if adverse reactions occur. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Absolute contraindications for Setria Glutathione are generally limited due to its natural presence in the body. However, individuals with known hypersensitivity or allergic reactions to glutathione or any ingredients in the specific supplement formulation should avoid its use. While robust contraindications are rare, individuals with certain medical conditions, especially those related to impaired sulfur metabolism or severe liver/kidney disease, should consult a healthcare professional before starting any new supplement. As a general precaution, individuals undergoing active treatments for cancer should discuss all supplements with their oncologist, as antioxidants can sometimes interact with certain therapies. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
While glutathione is generally considered safe, there is limited comprehensive data on its interactions with all medications and supplements. It is generally advisable to inform your healthcare provider about all supplements you are taking. Caution should be exercised with:
* **Chemotherapy Agents:** Some theoretical concerns exist regarding antioxidant supplements and their potential to interfere with the efficacy of certain chemotherapy drugs that rely on oxidative stress to kill cancer cells (though this is a complex area of ongoing research and not definitively established for all agents).
* **Sulfonamides:** Individuals with sulfa allergies should be cautious, although glutathione itself does not contain sulfur in the same chemical structure as sulfonamide antibiotics. Still, potential sensitivities warrant discussion with a clinician.
Always discuss your full medication and supplement regimen with a healthcare professional to identify potential interactions. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Setria Glutathione is typically recommended to be taken in the morning. However, the precise timing relative to meals (either with food or on an empty stomach) may vary depending on the specific product formulation and individual tolerance. Some manufacturers suggest taking it with a meal to minimize potential gastrointestinal upset. Consistency in daily intake is often emphasized to support steady levels. Individual needs vary — talk to a licensed clinician.
Put it into practice
Reading about Setria Glutathione is the first step — DoseRoutine helps you act on it. These free tools turn what you just learned into a routine.
What interacts with Setria Glutathione?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Any glp1 + supplement | Note | Category ruleConfidence: theoretical | GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.Source pending | Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider. |
| Any supplement + medication | Note | Category ruleConfidence: theoretical | Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).Source pending | Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist. |
Frequently asked questions about Setria Glutathione
Setria Glutathione is a supplement. The references summarized come from NIH and PubMed records, FDA labeling where it exists, and Mayo Clinic patient material.
Setria Glutathione is commonly discussed in the context of supporting immune. Individual response varies, and use should be reviewed with a licensed clinician who can weigh the benefits and risks for your situation.
For Setria Glutathione, it is typically taken in the morning. Always follow the specific dose your clinician or the product label prescribes.
Setria Glutathione carries potential side effects and drug interactions, documented in NIH, Mayo Clinic, and FDA label sources. Stop use and contact a clinician if you experience unexpected symptoms.
As a supplement, Setria Glutathione can overlap with other supplements, prescription medicines, hormones and peptides. Because Setria Glutathione is usually taken in the morning, most avoidable conflicts come from what else lands in that same window. Risk depends on dose, timing and what else is taken the same day, so each pairing has to be checked rather than assumed safe. The free checker at https://doseroutine.com/interaction-checker covers Setria Glutathione with no sign-up.
Whether Setria Glutathione fits alongside testosterone replacement therapy depends on the protocol — dose, ester and ancillaries such as HCG or anastrozole — and on current bloodwork. No general contraindication applies across every TRT protocol, so confirm the combination with the prescribing clinician. See the free TRT interaction reference: https://doseroutine.com/trt-supplement-interactions
"Peptides" is not one category — healing peptides, GLP-1 agonists, growth-hormone secretagogues and melanocortins each behave differently next to Setria Glutathione. Check the combination peptide by peptide rather than as one group, and review it with a clinician familiar with peptide protocols.
Published frequency for Setria Glutathione varies by protocol and formulation, so the label or prescription is what sets it. It is typically taken in the morning. Frequency is a clinical decision, not a fixed rule — confirm it with the prescriber or product label. Comparison of apps that keep a schedule like this: https://doseroutine.com/best-dose-tracking-apps
The effect of a missed dose of Setria Glutathione depends on the protocol and formulation you are on. Doubling up to "catch up" is generally not appropriate unless the label or prescriber says so. Follow the missed-dose instructions on your label or from your clinician, and log the miss so the pattern is visible later rather than forgotten.
For Setria Glutathione the useful record is the dose, the time it was actually taken, and what else was taken in the same window. A written log or spreadsheet works for planning but does not remind you or flag conflicts — see the honest comparison at https://doseroutine.com/vs/spreadsheet and the wider roundup at https://doseroutine.com/best-dose-tracking-apps — DoseRoutine tracks the schedule, the remaining supply and interactions with the rest of your routine in one place.
Oral doses studied ranged from roughly 500 mg to 1,000 mg per day of reduced glutathione (as the Setria ingredient or comparable oral glutathione) in the cited crossover and combined-supplement trials. Route reported: Oral capsule or powder. Frequency reported: Once daily, or split doses, across trial durations of days to eight weeks. These are amounts documented in the cited studies and labels for Setria Glutathione — they are reported for reference, not a recommendation. Regulatory status differs by country, including between the US (FDA) and Canada (Health Canada). Confirm any amount with a licensed clinician before you take it.
Which studies looked at Setria Glutathione?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Randomized controlled trial of oral glutathione supplementation on body stores of glutathione(opens PubMed in a new tab)European journal of nutrition · 2015 · PMID 24791752 · https://pubmed.ncbi.nlm.nih.gov/24791752/
- 2.Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study(opens PubMed in a new tab)The Journal of dermatological treatment · 2012 · PMID 20524875 · https://pubmed.ncbi.nlm.nih.gov/20524875/
- 3.The clinical effect of glutathione on skin color and other related skin conditions: A systematic review(opens PubMed in a new tab)Journal of cosmetic dermatology · 2019 · PMID 30895708 · https://pubmed.ncbi.nlm.nih.gov/30895708/
- 4.Oral Glutathione and Growth in Cystic Fibrosis: A Multicenter, Randomized, Placebo-controlled, Double-blind Trial(opens PubMed in a new tab)Journal of pediatric gastroenterology and nutrition · 2020 · PMID 32960827 · https://pubmed.ncbi.nlm.nih.gov/32960827/
- 5.Effectiveness of oral glutathione in reducing nitric oxide and IL-1α concentrations for clinical improvement in mild to moderate acne vulgaris: a randomized controlled trial(opens PubMed in a new tab)Acta dermatovenerologica Alpina, Pannonica, et Adriatica · 2025 · PMID 41014073 · https://pubmed.ncbi.nlm.nih.gov/41014073/
Verify at
Publisher search links for Setria Glutathione. These are places to check the information — they are not citations, so they are not numbered.
- PubChem(publisher search, opens in a new tab)National Center for Biotechnology Information · publisher search
- NIH Office of Dietary Supplements(publisher search, opens in a new tab)National Institutes of Health · publisher search
- Mayo Clinic(publisher search, opens in a new tab)Mayo Clinic · publisher search
- Examine.com(publisher search, opens in a new tab)Examine.com · publisher search
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- DailyMed labeling archive(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on Setria Glutathione?
Plain-text summary, safe to quote verbatim:
Setria Glutathione is a patented form of glutathione, a tripeptide composed of three amino acids: L-cysteine, L-glutamic acid, and glycine. Research on Setria Glutathione focuses on immune function. It is typically taken in the morning. Dose, response, and interaction risk vary by individual, so use should be reviewed with a clinician.
Source: DoseRoutine — https://doseroutine.com/library/setria-glutathione
Setria Glutathione cheat sheet
DoseRoutine cheat sheet · Supplement
Setria Glutathione
Setria Glutathione is a patented form of glutathione, a tripeptide composed of three amino acids: L-cysteine, L-glutamic acid, and glycine.
Evidence
Strong
3 human randomized trials published.
Studied range
Oral doses studied ranged from roughly 500 mg to 1,000 mg per day of reduced glutathione (as the Setria ingredient or comparable oral glutathione) in the cited crossover and combined-supplement trials
Route
Oral capsule or powder
Frequency studied
Once daily, or split doses, across trial durations of days to eight weeks
Half-life
Not established as a standalone pharmacokinetic parameter in the cited human trials; the bioavailability trial tracked plasma/urinary glutathione metabolites over a single dosing day
Timing
in the morning
Not FDA-approvedOTC supplementSold in the US as a dietary supplement ingredient (branded as Setria by Kyowa Hakko); not FDA-approved as a drug and not evaluated by FDA for safety or efficacy claimsImmune
Key references
- A Targeted Metabolomic Assessment of Oral Glutathione Bioavailability and Safety in Humans: A Randomized Crossover Clinical Trial (2026)
- The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained males (2023)
- Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postmenopausal Women (2023)
Studied ranges, not dosing advice. Not medical advice — talk to a clinician. doseroutine.com/library/setria-glutathione
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). Setria Glutathione — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/setria-glutathione
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