
GHRP-6Benefits, Dosage & Interactions
GHRP-6, or Growth Hormone-Releasing Hexapeptide, is a synthetic peptide known for its ability to stimulate the release of growth hormone (GH) from the pituitary gland. It belongs to a class of compounds called growth hormone secretagogues. Research on GHRP-6 focuses on weight loss, tissue recovery, and muscle and strength.
How much GHRP-6 do people take?
The human sleep-endocrine study infused 50 µg intravenously at four time points across the night. Route reported: Intravenous in the published human study. Frequency reported: Repeated boluses within a single night in that protocol. These are amounts documented in the cited studies and labels for GHRP-6 — they are reported for reference, not a recommendation. Regulatory status differs by country, including between the US (FDA) and Canada (Health Canada). Confirm any amount with a licensed clinician before you take it.
See the full reported protocol and its sourcesResearched by DoseRoutine Research TeamReviewed for accuracy by Nicholas Alexander, RSE, SO, PMPLast updated Educational reference only — not medical advice. Always confirm dosing and safety decisions with a licensed clinician.
One published human randomized trial; results not yet replicated.
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
Worked example: a 5 mg vial reconstituted with 2 ml of bacteriostatic water gives 2.5 mg/ml, so a 100 mcg amount measures 4 units on a U-100 syringe. Open this in the reconstitution calculator.
Reported for GHRP-6 in the cited sources. Published ranges are not dosing advice.
Mixing GHRP-6: bacteriostatic water and syringe units
The vial arrives as dry powder. How much water you add sets the strength, and the strength sets the mark you draw to on the syringe. The table assumes a 5 mg vial and a 250 mcg example draw on a U-100 insulin syringe, where 100 units is one millilitre. If your vial is a different size, scale it — the arithmetic is the same.
| Bacteriostatic water added | Resulting strength | 250 mcg draws to |
|---|---|---|
| 1 mL | 5 mg/mL | 5 units |
| 2 mL | 2.5 mg/mL | 10 units |
| 3 mL | 1.67 mg/mL | 15 units |
Units, not millilitres. Insulin syringes are marked in units, and mixing up mcg and mg on a peptide label is the single most common error people report. Check the label twice. Run your own vial through the calculator.
Storage and stability
- Before mixing
- Sealed and still as a dry powder, GHRP-6 vials are normally kept in the fridge at 2–8 °C, out of light. Short spells at room temperature during shipping are the norm for lyophilized peptides and are not, on their own, a sign the vial is spoiled.
- After mixing
- Once bacteriostatic water goes in, the vial belongs in the fridge and is generally treated as good for about 28 days — that is how long the benzyl alcohol in bacteriostatic water is relied on to hold back bacterial growth. Plain sterile water has no preservative, so a vial mixed with it is a single-session vial. Never freeze a reconstituted vial.
- When to throw it out
- A properly mixed vial is clear. Cloudiness, floating strands, a color change or powder that will not go into solution after gentle swirling all mean the vial should be discarded rather than used. Shaking a peptide vial hard is the usual cause — swirl it, or run the water down the inside wall of the vial instead of onto the powder.
Handling and shelf-life figures describe general practice for lyophilized peptides. They are not a dose and not medical advice — your prescriber or the product label sets the amount.
GHRP-6 compared with similar compounds
| Attribute | GHRP-2 | GHRP-6 | Hexarelin | Ipamorelin |
|---|---|---|---|---|
| Class | Ghrelin receptor (GHS-R) agonist | Ghrelin receptor (GHS-R) agonist | Synthetic hexapeptide GH secretagogue | Selective ghrelin receptor (GHS-R) agonist |
| Route | Subcutaneous or intravenous | Intravenous in the published human work | Subcutaneous, intravenous or intranasal in studies | Subcutaneous injection |
| Half-life | ~1 hour | ~30–60 minutes | ~55 minutes | ~2 hours |
| Evidence grade | Limited | Limited | Limited | Preclinical |
| Oral stability | Not orally available | Not orally available | Poor oral bioavailability | Not orally available |
| Typical published cycle | Single-dose stimulation testing in the published work | Single or short repeated administration | Single-dose and short-course protocols | No established human protocol |
| Main studied use | Growth hormone stimulation testing | GH, ACTH and cortisol release; wound-healing research | Growth hormone release; cardiac research | Selective GH release without prolactin/cortisol rise |
References & evidence
Documents the GHRP-6 entry is written from. Each number matches an inline marker above.
- [1]Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal manFrieboes RM, Murck H, Maier P, et al. · Neuroendocrinology · 1995 · Peer-reviewed · PMID 7617137
- [2]Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome studyFernández-Mayola M, Betancourt L, Molina-Kautzman A, et al. · International Wound Journal · 2018 · Peer-reviewed · PMID 29464859
References & Evidence
Sources on this page that document GHRP-6 dosing, timing and safety.
- [1]National Center for Biotechnology Information View source
Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.
What is GHRP-6 studied for?
What is GHRP-6?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.
What does the research say about GHRP-6?
Tap a section to expand.
Source for this section: Sources for How does GHRP-6 work?: Jumps to this entry in the sources and references list at the end of the page.
Source for this section: Sources for When should you take GHRP-6?: Jumps to this entry in the sources and references list at the end of the page.
Put it into practice
Reading about GHRP-6 is the first step — DoseRoutine helps you act on it. These free tools turn what you just learned into a routine.
What interacts with GHRP-6?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Any peptide + hormone | Note | Category ruleConfidence: theoretical | Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.Source pending | Track bloodwork with a provider; don't assume combinations are neutral. |
Frequently asked questions about GHRP-6
Which studies looked at GHRP-6?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiency(opens PubMed in a new tab)J Pediatr Endocrinol Metab · 1996 · PMID 8887178 · https://pubmed.ncbi.nlm.nih.gov/8887178/
Sources cited on this page
Specific documents referenced by the numbered markers above. Each number matches the marker in the text.
- PubChem CID 4345065(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/4345065
Verify at
Publisher search links for GHRP-6. These are places to check the information — they are not citations, so they are not numbered.
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- NIH Office of Dietary Supplements(publisher search, opens in a new tab)National Institutes of Health · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- DailyMed labeling archive(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on GHRP-6?
Plain-text summary, safe to quote verbatim:
GHRP-6, or Growth Hormone-Releasing Hexapeptide, is a synthetic peptide known for its ability to stimulate the release of growth hormone (GH) from the pituitary gland. It belongs to a class of compounds called growth hormone secretagogues. Research on GHRP-6 focuses on weight loss, tissue recovery, and muscle and strength.
GHRP-6 cheat sheet
DoseRoutine cheat sheet · Peptide
GHRP-6
GHRP-6, or Growth Hormone-Releasing Hexapeptide, is a synthetic peptide known for its ability to stimulate the release of growth hormone (GH) from the pituitary gland. It belongs to a class of compounds called growth hormone secretagogues.
Evidence
Moderate
One published human randomized trial; results not yet replicated.
Studied range
The human sleep-endocrine study infused 50 µg intravenously at four time points across the night
Route
Intravenous in the published human study
Frequency studied
Repeated boluses within a single night in that protocol
Half-life
~0.9 h
Timing
in the evening
Storage
Lyophilized peptide refrigerated and protected from light
Studied ranges, not dosing advice. Not medical advice — talk to a clinician. doseroutine.com/library/ghrp-6
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). GHRP-6 — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/ghrp-6
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