vitaminOTC supplementNiacin is available both as an FDA-approved prescription lipid-lowering medication (at gram-level doses) and as an over-the-counter dietary supplement at much lower nutrient dosesReviews note that later cardiovascular outcome trials weakened confidence in the HDL-raising rationale for high-dose niacin therapy, even though it remains FDA-approved
Vitamin B3 (Niacin)Benefits, Dosage & Interactions
Also known as: Niacin, B3
Vitamin B3, also known as niacin, is an essential water-soluble vitamin. It plays a crucial role in numerous metabolic processes, including converting food into energy, supporting cellular function, and maintaining DNA integrity. Research on Vitamin B3 (Niacin) focuses on heart and circulatory health.
Researched by DoseRoutine R&D TeamReviewed for accuracy by Nicholas Alexander, RSELast updated
Evidence: Insufficient — No primary literature attached to this entry yet.
Evidence strengthInsufficient — nothing graded yet
PreclinicalStrong human evidence
No primary literature attached to this entry yet.
Whole-body biological half-life
Not applicable
Typical timing
with meal
Food rule
with food
Default unit
mg
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
- Reported amounts
- Cardiovascular literature describes prescription niacin for lipid management at 1–2 g/day, well above the roughly 14–16 mg/day dietary requirement, with therapy usually started at lower doses and titrated up to limit flushing[1][2]
- Route studied
- Oral, as immediate-release or extended-release tablets in the cited cardiovascular literature[1][2]
- Frequency
- Once or twice daily depending on formulation (immediate-release vs. extended-release), per the cited reviews[1][2]
Reported for Vitamin B3 (Niacin) in the cited sources. Published ranges are not dosing advice.
References & evidence
Documents the Vitamin B3 (Niacin) entry is written from. Each number matches an inline marker above.
- [1]Niacin and cholesterol: role in cardiovascular disease (review)Ganji SH, Kamanna VS, Kashyap ML · The Journal of Nutritional Biochemistry · 2003 · Peer-reviewed · PMID 12873710
- [2]Niacin Therapy, HDL Cholesterol, and Cardiovascular Disease: Is the HDL Hypothesis Defunct?Mani P, Rohatgi A · Current Atherosclerosis Reports · 2015 · Peer-reviewed · PMID 26048725
- [3]Niacin promotes the efflux of lysosomal cholesterol from macrophages via the CD38/NAADP signaling pathwayYang S, Zhang F, Li Q, Li Q · Experimental Biology and Medicine · 2022 · Peer-reviewed · PMID 35369785
How to track Vitamin B3 (Niacin) doses
Tracking Vitamin B3 (Niacin) well takes four fields and a habit. Here is what to record so the log is still useful in three months.
- 1
Add the dose and unit
Log Vitamin B3 (Niacin) with its dose in mg so totals stay comparable over time — including days when you split the dose or skip it.
- 2
Set the time of day and food rule
Typical timing is with_meal. Take it with food, and record it that way so absorption stays consistent. Reminders fire at that time and can export to your calendar.
- 3
Check it against the rest of the stack
Run Vitamin B3 (Niacin) through the interaction checker against everything else in the routine — supplements, peptides, hormones and prescriptions — before it becomes a daily habit.
- 4
Log adherence, not intentions
Mark each dose taken, skipped or delayed as it happens. Weeks of honest logs are what make an adherence rate or a trend line meaningful; retrospective guessing is not.
- 5
Review against outcomes
Review Vitamin B3 (Niacin) alongside your logged metrics and any relevant blood work every few weeks before changing the dose, so the change is a response to data rather than to a good or bad day.
What to log each time
- Dose in mg
- Time of day and whether it was taken with food
- Taken / skipped / delayed
- Any side effects or notable changes
References & Evidence
Sources on this page that document Vitamin B3 (Niacin) dosing, timing and safety.
- [1]National Center for Biotechnology Information View source
Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.
What is Vitamin B3 (Niacin) studied for?
Deficiency-driven — not a performance booster
Vitamins primarily help when you're actually low. Extra doses on top of normal levels rarely add strength, endurance, or fat loss, and some fat-soluble vitamins (A, D, E, K) can build up to harmful levels.
- Confirm a deficiency with bloodwork before supplementing long-term (e.g. 25(OH)D for vitamin D, B12/folate, ferritin, magnesium RBC).
- Talk to your doctor or a registered dietitian about the right dose for your labs, medications, and conditions — especially in pregnancy, kidney/liver disease, or while on blood thinners.
- Re-test every 3–6 months and stop or lower the dose once levels are in range.
Educational information only — not medical advice. See our AI & medical policy.
What is Vitamin B3 (Niacin)?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.
Vitamin B3, also known as niacin, is an essential water-soluble vitamin. It plays a crucial role in numerous metabolic processes, including converting food into energy, supporting cellular function, and maintaining DNA integrity. Niacin exists in several forms, primarily nicotinic acid and nicotinamide (also called niacinamide). Both forms can be obtained through diet or supplements and serve as precursors for essential coenzymes, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). These coenzymes are vital for over 400 enzymatic reactions in the body, participating in energy metabolism, antioxidant defense, and cell signaling (NIH ODS, PubChem).
Historically, niacin deficiency, known as pellagra, was a significant public health problem characterized by dermatitis, diarrhea, and dementia. While rare in developed countries today due to fortified foods, understanding its role is still important. Niacin's pharmacological effects, particularly with nicotinic acid at higher doses, extend beyond preventing deficiency and have been studied for their impact on lipid profiles and cardiovascular health (Mayo Clinic, MedlinePlus).
The body can synthesize some niacin from the amino acid tryptophan, though this process is not efficient enough to meet daily requirements without dietary intake. Good dietary sources of niacin include meat, poultry, fish, nuts, legumes, and fortified cereals. Nicotinic acid and nicotinamide are commonly found in dietary supplements. Notably, nicotinic acid and nicotinamide have distinct physiological effects, especially at higher doses, with nicotinic acid being more commonly associated with lipid-modifying properties and specific side effects like the "niacin flush" (NIH ODS, DrugBank).
Why vitamins for endurance: Niacin (as NAD precursor) supports mitochondrial energy production. Deficiency is rare in developed diets, so most people will not feel a performance change from added niacin.
References: NIH ODS Niacin fact sheet (2022).
What does the research say about Vitamin B3 (Niacin)?
Tap a section to expand.
Niacin functions primarily as a precursor to the coenzymes NAD and NADP. These coenzymes are critical in various metabolic pathways. NAD, in its oxidized form (NAD+), acts as an electron acceptor in catabolic reactions, where complex molecules are broken down to release energy. In its reduced form (NADH), it donates electrons in anabolic reactions, which build complex molecules, and in the electron transport chain, a key process for ATP production in mitochondria. This involvement underscores niacin's role in energy metabolism and mitochondrial function (PubChem, NIH ODS).
NADP, particularly in its reduced form (NADPH), is essential for anabolic pathways such as fatty acid and cholesterol synthesis, and for maintaining the body's antioxidant defenses. NADPH is a key component of the glutathione reductase system, which helps protect cells from oxidative stress. It is also central to the pentose phosphate pathway, which generates precursors for nucleotide synthesis. The roles of NAD and NADP extend to DNA repair, cell signaling, and gene expression, highlighting niacin's broad impact on cellular health and longevity (PubChem, MedlinePlus).
At pharmacologic doses, particularly of nicotinic acid, niacin exerts distinct mechanisms beyond its coenzyme functions. One well-studied mechanism involves its interaction with the hydroxycarboxylic acid receptor 2 (HCAR2), also known as GPR109A. Activation of HCAR2 on adipose tissue leads to a reduction in lipolysis, the breakdown of triglycerides into free fatty acids. This reduction in free fatty acid release to the liver decreases hepatic triglyceride synthesis and very-low-density lipoprotein (VLDL) production, subsequently lowering LDL cholesterol and increasing HDL cholesterol (DrugBank, PubMed review). This specific mechanism differentiates nicotinic acid's effects on lipid profiles from those of nicotinamide.
Source for this section: Sources for How does Vitamin B3 (Niacin) work?: Jumps to this entry in the sources and references list at the end of the page.
The benefits of Vitamin B3 (niacin) are diverse, ranging from preventing deficiency symptoms to supporting metabolic health when used at higher doses.
* **Pellagra Prevention and Treatment:** As an essential nutrient, niacin is crucial for preventing and treating pellagra, a deficiency disease characterized by skin rashes, digestive issues, and neurological problems. This is its most fundamental and well-established benefit globally (NIH ODS, MedlinePlus).
* **Cardiovascular Health (Nicotinic Acid):** Pharmacological doses of nicotinic acid have been shown to positively influence lipid profiles, particularly by raising high-density lipoprotein (HDL) cholesterol (often called 'good' cholesterol), lowering low-density lipoprotein (LDL) cholesterol, and reducing triglycerides. These actions contribute to its historical use in managing dyslipidemia and are subjects of ongoing research regarding overall cardiovascular event reduction (Mayo Clinic, Cochrane Review).
* **Energy Metabolism and Mitochondrial Function:** Through its role as a precursor to NAD and NADP, niacin is integral to the body's ability to convert carbohydrates, fats, and proteins into energy. This is fundamental for cellular respiration and efficient mitochondrial function, which are critical for overall vitality and cellular health (PubChem, NIH ODS).
* **Antioxidant Support:** NADP is vital for the generation of NADPH, a key component in antioxidant systems like the glutathione reductase pathway. This contributes to protecting cells from oxidative damage, which is implicated in aging and various chronic diseases (PubChem).
* **Brain Function and Nervous System Support:** Niacin plays a role in nerve signaling and DNA repair, which are essential for maintaining healthy brain function and supporting the nervous system. Deficiency can lead to neurological symptoms, underscoring its importance for cognitive health (MedlinePlus).
* **Skin Health:** Niacinamide, a form of Vitamin B3, is often found in topical skincare products due to its potential to support skin barrier function, reduce inflammation, and improve the appearance of fine lines and hyperpigmentation (PubMed review, dermatologist consensus). Oral niacin also helps maintain skin integrity as part of its role in preventing pellagra.
Evidence for Vitamin B3's effects comes from various types of studies. The role of niacin in preventing and treating pellagra is unequivocally established through clinical observation and intervention studies as a public health measure. This foundational understanding is supported by major health organizations (NIH ODS, WHO).
For its cardiovascular benefits, particularly with nicotinic acid, evidence is primarily derived from clinical trials. Large-scale studies have demonstrated that high-dose nicotinic acid can significantly alter lipid profiles, including increasing HDL cholesterol and lowering triglycerides and LDL cholesterol (Cochrane Review, Mayo Clinic). However, the benefits on hard cardiovascular endpoints (e.g., heart attack, stroke) when added to statin therapy have been a subject of debate following some randomized controlled trials that did not show additional event reduction or showed an increase in certain adverse events despite favorable lipid changes (New England Journal of Medicine research). This highlights the complexity of interpreting lipid modification in the context of overall clinical outcomes.
Regarding energy metabolism and general cellular function, the evidence is robust at a biochemical level, given niacin's integral role as a cofactor for NAD and NADP in hundreds of enzymatic reactions. This mechanistic understanding is supported by extensive basic science research (PubChem, textbooks of biochemistry).
For specific applications like skin health with niacinamide, evidence includes both in vitro studies, animal models, and human clinical trials demonstrating benefits such as improved skin barrier function and reduced inflammation (dermatology journals). While promising, the extent and clinical significance of these benefits can vary. It is important to differentiate between the forms of niacin and the specific applications when evaluating the body of evidence for Vitamin B3.
Side effects of Vitamin B3 can vary significantly depending on the form (nicotinic acid vs. nicotinamide), dosage, and individual sensitivity.
* **Niacin Flush:** The most common and well-known side effect of nicotinic acid, especially at higher doses, is the 'niacin flush.' This involves redness, warmth, itching, and tingling of the skin, typically on the face, neck, and chest. It is caused by the release of prostaglandins and is usually harmless but can be uncomfortable. It often lessens over time with continued use. Extended-release forms of nicotinic acid are designed to reduce flushing, though they may carry other risks (Mayo Clinic, DrugBank).
* **Gastrointestinal Issues:** Nausea, vomiting, diarrhea, indigestion, and abdominal pain are possible, particularly with higher doses of both nicotinic acid and nicotinamide (MedlinePlus).
* **Liver Problems:** High doses of niacin, particularly slow-release or timed-release nicotinic acid, have been associated with elevated liver enzymes and, in rare cases, liver damage, including liver failure. Regular liver function monitoring is crucial for individuals on high-dose niacin therapy (Mayo Clinic, FDA label).
* **Hyperglycemia/Insulin Resistance:** Niacin, particularly nicotinic acid, can sometimes impact blood sugar control, potentially worsening insulin resistance or glucose tolerance, especially in individuals with diabetes or pre-diabetes (NIH ODS).
* **Gout/Hyperuricemia:** Niacin can increase uric acid levels in the blood, which may exacerbate or precipitate gout attacks in susceptible individuals (DrugBank).
* **Ocular Effects:** Macular edema and blurred vision have been reported rarely with high doses of niacin (FDA label).
* **Hypotension:** Niacin can cause a drop in blood pressure, especially when initiating therapy or increasing dosage (DrugBank).
This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Several warnings are associated with Vitamin B3, particularly when taken in supplemental or pharmacological doses.
* **Liver Monitoring:** Individuals taking high doses of niacin (especially nicotinic acid) should undergo regular liver function tests, as there is a risk of hepatotoxicity. Symptoms of liver problems, such as persistent nausea, unusual fatigue, dark urine, and yellowing of the skin or eyes, warrant immediate medical attention (Mayo Clinic, FDA label).
* **Blood Sugar Control:** Niacin can affect glucose metabolism. Individuals with diabetes or those at risk of diabetes should monitor their blood glucose levels closely if taking niacin, as it may necessitate adjustments to antidiabetic medications (MedlinePlus).
* **Hypotension Risk:** Niacin can cause vasodilation and lower blood pressure. Caution is advised for individuals with low blood pressure or those taking antihypertensive medications due to the risk of additive hypotensive effects, particularly when standing up quickly (DrugBank).
* **Gout Risk:** Niacin can increase serum uric acid levels. Individuals with a history of gout or hyperuricemia should use niacin with caution and monitor their uric acid levels (NIH ODS).
* **Gallbladder Disease:** Caution is advised for individuals with a history of gallbladder disease (FDA label).
* **Allergic Reactions:** While the niacin flush is common and typically not an allergic reaction, true allergic reactions, though rare, can occur (DrugBank).
* **Form-Specific Considerations:** It is crucial to distinguish between nicotinic acid and nicotinamide (niacinamide). Nicotinic acid is associated with the 'flush' and lipid-modifying effects, while nicotinamide typically does not cause flushing and has different therapeutic applications, often related to skin health or specific inflammatory conditions (NIH ODS).
This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Vitamin B3, particularly in its nicotinic acid form and at higher doses, is contraindicated in certain conditions to prevent serious adverse effects.
* **Active Liver Disease or Unexplained Persistent Elevations of Serum Transaminases:** Due to the risk of hepatotoxicity, niacin should not be used in individuals with active liver disease or significantly elevated liver enzymes (Mayo Clinic, FDA label).
* **Active Peptic Ulcer Disease:** The vasodilatory effects and potential for gastrointestinal upset associated with niacin can exacerbate peptic ulcer disease (DrugBank).
* **Severe Hypotension:** In conditions where low blood pressure is already a concern or potentially dangerous, niacin's blood pressure-lowering effects could be harmful (DrugBank).
* **Arterial Hemorrhage:** Due to its vasodilatory properties, niacin is contraindicated in situations involving acute or significant bleeding (FDA label).
* **Known Hypersensitivity to Niacin:** Individuals who have had a severe allergic reaction to niacin or its derivatives should avoid further use (DrugBank).
It is essential to consult a healthcare professional to assess individual risk factors before considering niacin supplementation, especially at higher doses.
This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Combining Vitamin B3 (niacin) with certain medications or substances can lead to adverse interactions or reduced efficacy.
* **Statins:** While niacin is sometimes co-administered with statins for lipid management, the combination can increase the risk of myopathy (muscle pain/weakness) and rhabdomyolysis (severe muscle breakdown), particularly with higher doses of statins and/or extended-release niacin (FDA label, Mayo Clinic). Close monitoring by a clinician is essential if these are combined.
* **Antihypertensive Medications:** Niacin's vasodilatory effects can add to the blood pressure-lowering effects of antihypertensive drugs, potentially leading to excessive drops in blood pressure (hypotension) and dizziness (DrugBank).
* **Anticoagulants/Antiplatelet Drugs:** Niacin may have minor antiplatelet effects, theoretically increasing the risk of bleeding when combined with blood thinners like warfarin, aspirin, or other antiplatelet agents (MedlinePlus).
* **Alcohol:** Consuming alcohol with niacin can worsen the 'niacin flush' and may increase the risk of liver toxicity, especially with high doses of niacin (NIH ODS).
* **Nicotine Patches/Gum:** Nicotine in other forms can also cause vasodilation, potentially intensifying the niacin flush or other side effects (clinician observation).
* **Other Hepatotoxic Medications:** Due to niacin's potential for liver toxicity, combining it with other medications known to be liver toxic (e.g., certain antifungals, acetaminophen in high doses) may increase the risk of liver damage (DrugBank).
* **Chromium Picolinate:** Some evidence suggests a theoretical increased risk of insulin resistance when chromium and niacin are co-administered, though clinical significance is still under investigation (research observation).
* **Topical Niacinamide with Vitamin C:** While not a contraindication, some anecdotal reports and in vitro studies suggest that high concentrations of topical niacinamide and L-ascorbic acid (Vitamin C) applied consecutively might react to form nicotinic acid, potentially causing transient redness. However, modern formulations generally mitigate this concern, and many products successfully combine these ingredients (cosmetic chemistry literature).
This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Vitamin B3 (niacin) is typically recommended to be consumed with meals to minimize gastrointestinal upset. When taken as a supplement, the timing can influence the experience of side effects, particularly the 'niacin flush.'
* **With Meals:** Taking niacin with food, rather than on an empty stomach, can help to reduce common gastrointestinal side effects like nausea, indigestion, and stomach upset. For nicotinic acid, eating a meal before taking the dose can also help to temper the intensity of the 'niacin flush' by slowing absorption (Mayo Clinic).
* **Evening Dosing:** Some individuals taking higher doses of immediate-release nicotinic acid prefer to take it at bedtime after a light snack to sleep through the flush symptoms. However, extended-release formulations are often designed to be taken once daily, sometimes in the evening, to provide sustained release and reduce the intensity of flushing (DrugBank, FDA label).
* **As Directed by Clinician:** For pharmacological doses, especially of nicotinic acid, a licensed clinician will provide specific dosing instructions that account for the form of niacin, individual tolerance, and concurrent medications. This may involve starting with a low dose and gradually increasing it to improve tolerability (Mayo Clinic).
* **Around Exercise:** There is no specific evidence to suggest benefits or harms from timing niacin specifically around exercise, but general advice to take with food remains relevant. Some theoretical concerns exist about high doses of nicotinic acid acutely impairing fat oxidation during exercise, but this is generally not relevant for typical supplementation (sports physiology research).
Individual needs vary significantly, and the optimal timing depends on the specific form of niacin being used, the dosage, and personal tolerance. Always follow the advice of a qualified clinician for specific guidance.
Source for this section: Sources for When should you take Vitamin B3 (Niacin)?: Jumps to this entry in the sources and references list at the end of the page.
What interacts with Vitamin B3 (Niacin)?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Any vitamin + medication | Note | Category ruleConfidence: theoretical | Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).Source pending | Specific pairs are checked against a licensed source; confirm with your provider. |
Frequently asked questions about Vitamin B3 (Niacin)
Nicotinic acid and niacinamide are both forms of Vitamin B3, but they have distinct effects, particularly at higher doses. Nicotinic acid is primarily used to affect cholesterol levels, and is known for causing the 'niacin flush' (redness, itching, warmth). Niacinamide typically does not cause the flush and is more often used for skin health or as a general vitamin B3 supplement without the lipid-modifying effects (NIH ODS).
While niacin plays a crucial role in overall nervous system function and energy metabolism, there is limited direct, strong evidence to support its standalone use specifically for treating anxiety or sleep disorders. Some individuals report improvements, possibly due to its role in neurotransmitter synthesis, but it is not a primary recommended treatment (MedlinePlus, general medical consensus).
The 'niacin flush' is generally harmless and is a common side effect of nicotinic acid, particularly at higher doses. It's caused by the release of prostaglandins and typically manifests as redness, warmth, itching, and tingling of the skin. While uncomfortable, it usually lessens over time as the body adapts. However, severe or accompanied by other symptoms, it warrants medical review (Mayo Clinic, DrugBank).
The tolerable upper intake level (UL) for niacin from supplements, for adults, is 35 mg per day, primarily to avoid the flush. However, much higher doses of nicotinic acid (hundreds to thousands of milligrams daily) are used under medical supervision for lipid-lowering purposes. At these pharmacological doses, risks of liver damage, blood sugar issues, and other serious side effects increase considerably. 'Too much' depends on the form, individual health, and duration of use, and must be determined by a clinician (NIH ODS).
Yes, most people in developed countries can obtain sufficient niacin through a balanced diet, as it is found in many foods like meat, poultry, fish, nuts, legumes, and fortified cereals. Niacin deficiency (pellagra) is rare in places where food is abundant and fortified. Supplementation is typically considered for specific therapeutic reasons or if deficiency is diagnosed (NIH ODS).
Interaction risk for Vitamin B3 (Niacin) comes from the rest of the stack: other vitamins, prescription medicines, hormone therapy and peptides. Because Vitamin B3 (Niacin) is usually taken with a meal, most avoidable conflicts come from what else lands in that same window. Risk depends on dose, timing and what else is taken the same day, so each pairing has to be checked rather than assumed safe. The free checker at https://doseroutine.com/interaction-checker covers Vitamin B3 (Niacin) with no sign-up.
There is no single answer for Vitamin B3 (Niacin) plus TRT. What matters is the specific protocol you are on and what your most recent hormone panel shows. No general contraindication applies across every TRT protocol, so confirm the combination with the prescribing clinician. See the free TRT interaction reference: https://doseroutine.com/trt-supplement-interactions
Pairing Vitamin B3 (Niacin) with peptides has to be assessed one peptide at a time, because GLP-1 agonists, secretagogues, healing peptides and melanocortins do not share an interaction profile. Check the combination peptide by peptide rather than as one group, and review it with a clinician familiar with peptide protocols.
Published frequency for Vitamin B3 (Niacin) varies by protocol and formulation, so the label or prescription is what sets it. It is typically taken with a meal. Most protocols have it taken with food. Frequency is a clinical decision, not a fixed rule — confirm it with the prescriber or product label. Comparison of apps that keep a schedule like this: https://doseroutine.com/best-dose-tracking-apps
The effect of a missed dose of Vitamin B3 (Niacin) depends on the protocol and formulation you are on. Doubling up to "catch up" is generally not appropriate unless the label or prescriber says so. Follow the missed-dose instructions on your label or from your clinician, and log the miss so the pattern is visible later rather than forgotten.
For Vitamin B3 (Niacin) the useful record is the dose, the time it was actually taken, and what else was taken in the same window. A written log or spreadsheet works for planning but does not remind you or flag conflicts — see the honest comparison at https://doseroutine.com/vs/spreadsheet and the wider roundup at https://doseroutine.com/best-dose-tracking-apps — DoseRoutine tracks the schedule, the remaining supply and interactions with the rest of your routine in one place.
Which studies looked at Vitamin B3 (Niacin)?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Nutrition Information Briefs - Niacin(opens PubMed in a new tab)Adv Nutr · 2026 · PMID 42107767 · https://pubmed.ncbi.nlm.nih.gov/42107767/
Sources cited on this page
Specific documents referenced by the numbered markers above. Each number matches the marker in the text.
- PubChem CID 938(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/938
Verify at
Publisher search links for Vitamin B3 (Niacin). These are places to check the information — they are not citations, so they are not numbered.
- NIH Office of Dietary Supplements(publisher search, opens in a new tab)National Institutes of Health · publisher search
- MedlinePlus(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- Mayo Clinic(publisher search, opens in a new tab)Mayo Clinic · publisher search
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- FDA-approved labeling (DailyMed)(publisher search, opens in a new tab)U.S. Food and Drug Administration · publisher search
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- Wikipedia entry(publisher search, opens in a new tab)Wikipedia · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on Vitamin B3 (Niacin)?
Plain-text summary, safe to quote verbatim:
Vitamin B3, also known as niacin, is an essential water-soluble vitamin. It plays a crucial role in numerous metabolic processes, including converting food into energy, supporting cellular function, and maintaining DNA integrity. Research on Vitamin B3 (Niacin) focuses on heart and circulatory health.
Source: DoseRoutine — https://doseroutine.com/library/vitamin-b3-niacin
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). Vitamin B3 (Niacin) — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/vitamin-b3-niacin
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