supplement

Pine Bark Extract

Also known as: Pycnogenol, Maritime pine

Evidence: High · 90%
Half-life
6 h
Typical timing
any
Food rule
with food
Default unit

Studied for

Overview

A patented, standardized proanthocyanidin extract with more than 400 clinical studies for cardiovascular, endothelial and skin outcomes.

Deep dive

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Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

Frequently asked

Sources referenced

- Ledda A et al. Investigation of a complex plant extract for mild to moderate erectile dysfunction (Pycnogenol + L-arginine). BJU Int 2010.\n- Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol). Int J Clin Pharmacol Ther 2002.

DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Cite this page

Using this in an article, AI answer, or research note? Please attribute:

DoseRoutine. (2026). Pine Bark Extract — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/pine-bark-extract
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