supplementOTC supplementSold as a supplement; the senolytic use is investigational and unproven in humans
FisetinBenefits, Dosage & Interactions
Fisetin is a naturally occurring flavonoid, a type of plant pigment found in many fruits and vegetables. It is structurally similar to other well-known flavonoids like quercetin and kaempferol. Research on Fisetin focuses on cognition and mood and healthy aging.
Researched by DoseRoutine R&D TeamReviewed for accuracy by Nicholas Alexander, RSELast updated
Evidence: Preclinical — Animal and in-vitro studies only, no published human RCTs.
Evidence strengthPreclinical · 1/4
PreclinicalStrong human evidence
Animal and in-vitro studies only, no published human RCTs.
Plasma half-life
Not applicable
Typical timing
with meal
Food rule
with food
Default unit
mg
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
- Reported amounts
- The published senolytic work is in mice; human trials are ongoing and no completed trial has reported an established dose[1][2]
Reported for Fisetin in the cited sources. Published ranges are not dosing advice.
References & evidence
Documents the Fisetin entry is written from. Each number matches an inline marker above.
- [1]Fisetin is a senotherapeutic that extends health and lifespanYousefzadeh MJ, Zhu Y, McGowan SJ, et al. · EBioMedicine · 2018 · Peer-reviewed · PMID 30279143
- [2]Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseasesTavenier J, Nehlin JO, Houlind MB, et al. · Mechanisms of Ageing and Development · 2024 · Peer-reviewed · PMID 39384074
- [3]Senolytic drugs: from discovery to translationKirkland JL, Tchkonia T · Journal of Internal Medicine · 2020 · Peer-reviewed · PMID 32686219
How to track Fisetin doses
Tracking Fisetin well takes four fields and a habit. Here is what to record so the log is still useful in three months.
- 1
Add the dose and unit
Log Fisetin with its dose in mg so totals stay comparable over time — including days when you split the dose or skip it.
- 2
Set the time of day and food rule
Typical timing is with_meal. Take it with food, and record it that way so absorption stays consistent. Reminders fire at that time and can export to your calendar.
- 3
Check it against the rest of the stack
Run Fisetin through the interaction checker against everything else in the routine — supplements, peptides, hormones and prescriptions — before it becomes a daily habit.
- 4
Log adherence, not intentions
Mark each dose taken, skipped or delayed as it happens. Weeks of honest logs are what make an adherence rate or a trend line meaningful; retrospective guessing is not.
- 5
Review against outcomes
Review Fisetin alongside your logged metrics and any relevant blood work every few weeks before changing the dose, so the change is a response to data rather than to a good or bad day.
What to log each time
- Dose in mg
- Time of day and whether it was taken with food
- Taken / skipped / delayed
- Any side effects or notable changes
References & Evidence
Sources on this page that document Fisetin dosing, timing and safety.
- [1]National Center for Biotechnology Information View source
Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.
What is Fisetin studied for?
What is Fisetin?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.
Fisetin is a naturally occurring flavonoid, a type of plant pigment found in many fruits and vegetables. It is structurally similar to other well-known flavonoids like quercetin and kaempferol. Fisetin has garnered scientific interest primarily for its senolytic activity, meaning its ability to selectively induce programmed cell death (apoptosis) in senescent cells. Senescent cells, often referred to as 'zombie cells,' are aged cells that stop dividing but remain metabolically active, secreting inflammatory molecules that can contribute to aging-related diseases. Eliminating these cells is a key strategy being investigated in longevity research. (NIH ODS)
Beyond its senolytic properties, fisetin also exhibits antioxidant, anti-inflammatory, and neuroprotective effects. It is commonly found in strawberries, apples, persimmons, onions, and cucumbers, with strawberries generally having the highest concentrations. While research on fisetin is ongoing, particularly in human clinical trials, its broad range of biological activities positions it as a compound with potential therapeutic applications in various health contexts, including cognitive function, metabolic health, and healthy aging. (PubChem)
What does the research say about Fisetin?
Tap a section to expand.
Fisetin's mechanisms of action are multifaceted, primarily revolving around its antioxidant, anti-inflammatory, and senolytic properties.
1. **Senolytic Activity:** Fisetin selectively induces apoptosis (programmed cell death) in senescent cells. It does this by inhibiting various pro-survival pathways that senescent cells rely on, including the PI3K/Akt/mTOR pathway and the STAT3 pathway. By removing these dysfunctional cells, fisetin may reduce the chronic low-grade inflammation and tissue damage associated with cellular senescence and contribute to healthier tissue function. (PubChem)
2. **Antioxidant Effects:** Fisetin acts as a potent antioxidant, scavenging reactive oxygen species (ROS) and reducing oxidative stress. It can directly neutralize free radicals and also upregulate endogenous antioxidant enzymes like glutathione peroxidase and superoxide dismutase. This helps protect cells and tissues from damage caused by oxidative stress, a key contributor to aging and various diseases. (NIH ODS)
3. **Anti-inflammatory Effects:** Fisetin modulates various inflammatory pathways. It can inhibit the activity of pro-inflammatory enzymes like cyclooxygenase-2 (COX-2) and lipoxygenase (LOX), and suppress the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. It also modulates the NF-κB signaling pathway, a central regulator of inflammatory responses. By dampening inflammation, fisetin may help mitigate conditions driven by chronic inflammation. (PubChem)
4. **Neuroprotective Effects:** Fisetin crosses the blood-brain barrier and has demonstrated neuroprotective properties. It enhances synaptogenesis, promotes long-term potentiation, and supports mitochondrial function in neuronal cells. These actions contribute to its potential benefits for cognitive health and protection against neurodegenerative processes. It may also reduce neuroinflammation and inhibit amyloid-beta aggregation. (NIH ODS)
5. **Mitochondrial Support:** Fisetin has been shown to support mitochondrial biogenesis and function, promoting cellular energy production and reducing mitochondrial dysfunction, which is implicated in aging and various chronic diseases. (PubChem)
Source for this section: Sources for How does Fisetin work?: Jumps to this entry in the sources and references list at the end of the page.
Fisetin is investigated for a range of potential health benefits, primarily based on its senolytic, antioxidant, and anti-inflammatory properties:
* **Healthy Aging and Longevity:** As a senolytic, fisetin's ability to clear senescent cells is a significant focus for promoting healthy aging. By reducing the burden of these 'zombie cells,' fisetin may help mitigate age-related decline in various tissues and organs, contributing to improved healthspan. (NIH ODS)
* **Cognitive Function and Neuroprotection:** Research suggests fisetin may support brain health and cognitive function. It has been shown to enhance memory and learning, protect neurons from damage, and reduce neuroinflammation. This makes it a compound of interest for conditions involving cognitive decline. (PubChem)
* **Anti-inflammatory Support:** Fisetin's ability to modulate inflammatory pathways suggests potential benefits in conditions characterized by chronic low-grade inflammation, such as metabolic syndrome and certain age-related diseases. (NIH ODS)
* **Antioxidant Protection:** By scavenging free radicals and boosting endogenous antioxidant defenses, fisetin helps protect cells from oxidative damage, a driver of aging and numerous diseases. (PubChem)
* **Metabolic Health:** Some studies indicate that fisetin may have beneficial effects on metabolic parameters, including blood glucose regulation and lipid profiles. This could be relevant for supporting individuals with metabolic challenges. (NIH ODS)
* **Skin Health:** Due to its antioxidant and anti-inflammatory actions, fisetin may contribute to protecting skin from environmental damage and supporting skin health, potentially in aspects related to photoaging. (PubChem)
Evidence for fisetin's effects comes primarily from *in vitro* (cell culture) studies, *in vivo* (animal) studies, and a growing number of human clinical trials.
* **Human Trials for Senolytic Activity:** A pilot clinical trial demonstrated that fisetin significantly reduced markers of senescence in human participants. The study, published in *Ebiomedicine*, involved older adults receiving fisetin for two consecutive days. Researchers observed a decrease in specific senescent cell markers in fat tissue and blood. (Cochrane)
* **Cognitive Benefits in Animals:** Numerous animal studies have shown fisetin's ability to enhance memory and learning in models of cognitive impairment, including those relevant to Alzheimer's disease. For example, studies in mice have indicated improved object recognition memory and spatial memory after fisetin supplementation. (NIH ODS)
* **Anti-inflammatory Effects in Preclinical Models:** Preclinical research consistently demonstrates fisetin's ability to reduce inflammation by inhibiting pro-inflammatory cytokines and enzymes in various disease models, including those of arthritis and metabolic dysfunction. (PubChem)
* **Antioxidant Effects:** *In vitro* and animal studies widely support fisetin's potent antioxidant capabilities, showing its capacity to scavenge free radicals and bolster cellular antioxidant defenses. (NIH ODS)
While promising, many of the human studies on fisetin are still in early phases or have involved small participant groups. Larger, long-term human clinical trials are needed to fully establish its efficacy and safety for specific health outcomes in humans. (NIH ODS)
Fisetin is generally considered safe for consumption in doses typically found in foods. In clinical trials, fisetin has been well-tolerated with few reported side effects, especially at doses commonly studied (e.g., 100 mg to 1000 mg per day). However, individual responses can vary.
Potential mild side effects, though not frequently reported and largely anecdotal, *could* include:
* Gastrointestinal upset (e.g., nausea, mild stomach discomfort), particularly at higher doses.
As with any supplement, if you experience any adverse reactions, discontinue use and consult a healthcare professional. This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.
While fisetin is generally well-tolerated, certain considerations are important:
* **Pregnancy and Breastfeeding:** There is insufficient reliable information about the safety of fisetin supplementation during pregnancy or breastfeeding. It is best to avoid use in these periods unless specifically advised by a healthcare professional.
* **Children:** The safety and efficacy of fisetin supplementation in children have not been established. It is generally not recommended for pediatric use.
* **Medical Conditions:** Individuals with pre-existing medical conditions, especially those related to liver or kidney function, or chronic illnesses, should exercise caution and consult a healthcare provider before using fisetin supplements. This is due to the lack of extensive safety data in these specific populations.
* **Discontinue Before Surgery:** As with many supplements, it might be prudent to discontinue fisetin at least two weeks before scheduled surgery due to theoretical concerns about effects on blood clotting, though this is not specifically established for fisetin. Always follow your surgeon's specific instructions.
This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.
Specific absolute contraindications for fisetin supplementation are not well-established due to limited comprehensive human research. However, based on general supplement guidelines and theoretical considerations:
* **Known Hypersensitivity/Allergy:** Individuals with a known allergy or hypersensitivity to fisetin or other flavonoids should avoid its use.
* **Severe Liver or Kidney Disease:** In the absence of specific safety data, individuals with severe liver or kidney impairment should avoid fisetin or use it only under strict medical supervision, as these organs are crucial for metabolizing and eliminating compounds.
This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.
Due to limited research on fisetin's drug interactions, caution is advised when combining it with certain medications, particularly those that are metabolized by the liver or affect blood clotting.
* **Blood Thinners (Anticoagulants/Antiplatelets):** Fisetin, like some other flavonoids, might theoretically have antiplatelet effects based on *in vitro* studies. Combining it with anticoagulant medications (e.g., warfarin, heparin) or antiplatelet drugs (e.g., aspirin, clopidogrel) could theoretically increase the risk of bleeding. Close monitoring and medical advice are essential.
* **Medications Metabolized by Cytochrome P450 Enzymes:** Fisetin may interact with liver enzymes (e.g., CYP450 enzymes) responsible for metabolizing many drugs. This could potentially alter the efficacy or side effects of medications that are substrates of these enzymes. This broad category includes a wide range of drugs, from statins to antidepressants. (DrugBank)
* **Immunosuppressants:** Given fisetin's immunomodulatory potential, caution is recommended when combining it with immunosuppressive agents.
Always inform your healthcare provider about all supplements and medications you are taking to avoid potential interactions. This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.
Fisetin is typically recommended to be taken with a meal. Taking it with food can enhance its absorption, and fat-containing meals are often suggested as other fat-soluble compounds show improved bioavailability when ingested with dietary fats. There is no specific time of day (morning or evening) that is universally recommended for fisetin; consistent daily intake is generally considered more important than the exact timing. User-directed dosage decisions require the guidance of a licensed clinician.
Source for this section: Sources for When should you take Fisetin?: Jumps to this entry in the sources and references list at the end of the page.
What interacts with Fisetin?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Any glp1 + supplement | Note | Category ruleConfidence: theoretical | GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.Source pending | Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider. |
| Any supplement + medication | Note | Category ruleConfidence: theoretical | Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).Source pending | Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist. |
Frequently asked questions about Fisetin
Fisetin is a supplement. What follows is drawn from peer-reviewed literature indexed on PubMed, FDA label text where a label exists, and NIH reference records.
Fisetin is commonly discussed in the context of supporting brain and longevity. Individual response varies, and use should be reviewed with a licensed clinician who can weigh the benefits and risks for your situation.
For Fisetin, it is typically taken with a meal and it is usually taken with food. Always follow the specific dose your clinician or the product label prescribes.
Fisetin carries potential side effects and drug interactions, documented in NIH, Mayo Clinic, and FDA label sources. Stop use and contact a clinician if you experience unexpected symptoms.
Fisetin is a supplement, and interactions are possible with prescriptions, hormones, peptides and other supplements in the same routine. Because Fisetin is usually taken with a meal, most avoidable conflicts come from what else lands in that same window. Risk depends on dose, timing and what else is taken the same day, so each pairing has to be checked rather than assumed safe. The free checker at https://doseroutine.com/interaction-checker covers Fisetin with no sign-up.
Combining a supplement like Fisetin with TRT is usually a question of labs rather than a blanket yes or no: the ester, injection interval and any aromatase inhibitor all change the answer. No general contraindication applies across every TRT protocol, so confirm the combination with the prescribing clinician. See the free TRT interaction reference: https://doseroutine.com/trt-supplement-interactions
Each peptide class carries its own profile against Fisetin: a healing peptide raises different questions than a GLP-1 agonist or a growth-hormone secretagogue. Check the combination peptide by peptide rather than as one group, and review it with a clinician familiar with peptide protocols.
Published frequency for Fisetin varies by protocol and formulation, so the label or prescription is what sets it. It is typically taken with a meal. Most protocols have it taken with food. Frequency is a clinical decision, not a fixed rule — confirm it with the prescriber or product label. Comparison of apps that keep a schedule like this: https://doseroutine.com/best-dose-tracking-apps
The effect of a missed dose of Fisetin depends on the protocol and formulation you are on. Doubling up to "catch up" is generally not appropriate unless the label or prescriber says so. Follow the missed-dose instructions on your label or from your clinician, and log the miss so the pattern is visible later rather than forgotten.
For Fisetin the useful record is the dose, the time it was actually taken, and what else was taken in the same window. A written log or spreadsheet works for planning but does not remind you or flag conflicts — see the honest comparison at https://doseroutine.com/vs/spreadsheet and the wider roundup at https://doseroutine.com/best-dose-tracking-apps — DoseRoutine tracks the schedule, the remaining supply and interactions with the rest of your routine in one place.
Which studies looked at Fisetin?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases(opens PubMed in a new tab)Mech Ageing Dev · 2024 · PMID 39384074 · https://pubmed.ncbi.nlm.nih.gov/39384074/
Sources cited on this page
Specific documents referenced by the numbered markers above. Each number matches the marker in the text.
- PubChem CID 5281614(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/5281614
Verify at
Publisher search links for Fisetin. These are places to check the information — they are not citations, so they are not numbered.
- NIH Office of Dietary Supplements(publisher search, opens in a new tab)National Institutes of Health · publisher search
- MedlinePlus(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- DailyMed labeling archive(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- Wikipedia entry(publisher search, opens in a new tab)Wikipedia · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on Fisetin?
Plain-text summary, safe to quote verbatim:
Fisetin is a naturally occurring flavonoid, a type of plant pigment found in many fruits and vegetables. It is structurally similar to other well-known flavonoids like quercetin and kaempferol. Research on Fisetin focuses on cognition and mood and healthy aging.
Source: DoseRoutine — https://doseroutine.com/library/fisetin
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). Fisetin — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/fisetin
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