peptideInjectable

Melanotan I

Also known as: MT-I, Afamelanotide

Evidence: High · 100%
Chemical structure of Melanotan I (PubChem CID 16197727)
Structure via PubChem
Half-life
25 h
Typical timing
any
Food rule
either
Default unit
mg

Studied for

Overview

Melanotan I, also known as afamelanotide, is a synthetic peptide that mimics the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). It acts as an agonist at melanocortin receptors, primarily the melanocortin 1 receptor (MC1R). The main therapeutic use of afamelanotide is to increase melanin production in the skin, providing photoprotection. It is specifically approved in some regions for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria (EPP), a rare genetic disorder characterized by severe photosensitivity. Afamelanotide is administered as a subcutaneous implant (FDA label).

Deep dive

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Known interactions

  • Category rule: peptide × hormone
    Note

    Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.

    Track bloodwork with a provider; don't assume combinations are neutral.

Frequently asked

Sources referenced

["U.S. Food and Drug Administration (FDA) label for Scenesse (afamelanotide)", "European Medicines Agency (EMA) Summary of Product Characteristics (SmPC) for Scenesse", "Cochrane Library"]

DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Cite this page

Using this in an article, AI answer, or research note? Please attribute:

DoseRoutine. (2026). Melanotan I — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/melanotan-i
Canonical URL

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