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peptideInjectableNo published human trials exist; Dihexa is sold only as an unregulated research chemical, not an approved or studied human therapeutic

DihexaBenefits, Dosage & Interactions

Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an experimental small peptide derived from angiotensin IV, studied in preclinical models for its ability to promote synapse formation through the hepatocyte growth factor / c-Met pathway. Interest comes from rodent work in Alzheimer's and Parkinson's models.

Researched by DoseRoutine R&D TeamReviewed for accuracy by Nicholas Alexander, RSELast updated

Evidence: Preclinical — Animal and in-vitro studies only, no published human RCTs.
Evidence strengthPreclinical · 1/4
PreclinicalStrong human evidence

Animal and in-vitro studies only, no published human RCTs.

Chemical structure of Dihexa (PubChem CID 129010512)
Structure via PubChem

Quick answer

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an experimental small peptide derived from angiotensin IV, studied in preclinical models for its ability to promote synapse formation through the hepatocyte growth factor / c-Met pathway. Interest comes from rodent work in Alzheimer's and Parkinson's models. It has never completed human clinical trials, is not approved by any regulator, and is sold only as an unregulated research chemical, so its human safety profile — including any effect on tumour-relevant growth signaling — is unknown.

Type
Synthetic angiotensin IV-derived peptidomimetic
Proposed mechanism
Potentiates hepatocyte growth factor / c-Met signaling
Evidence base
Rodent and in-vitro studies only
Regulatory status
Not approved; no completed human trials
Availability
Sold as a research chemical, not a medicine
Key unknown
Human dosing, long-term safety and cancer-risk signals

Compiled by DoseRoutine from public sources including NIH/MedlinePlus, the FDA label, Mayo Clinic and PubChem. Educational information, not medical advice.

Plasma half-life
Not established in humans; no published human pharmacokinetic data exists
Typical timing
morning
Default unit
mg

What published protocols report

Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.

Reported amounts
Only animal-dosing data exists; the mouse Alzheimer's-model study used intraperitoneal or intranasal Dihexa at milligram-per-kilogram doses, which does not translate to a human dose[1][2]
Route studied
Intraperitoneal or intranasal administration in the cited rodent and zebrafish studies[1][2]
Frequency
Daily dosing over several weeks in the mouse cognition study[1][2]
Cycle length
Rodent studies dosed for roughly 2 to 4 weeks[1][2]
Half-life
Not established in humans; no published human pharmacokinetic data exists[1][2]
Storage
Not established in the cited sources[1][2]

Reported for Dihexa in the cited sources. Published ranges are not dosing advice.

References & evidence

Documents the Dihexa entry is written from. Each number matches an inline marker above.

  1. [1]AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling PathwaySun X, Deng Y, Fu X, Wang S, Duan R, Zhang Y · Brain Sciences · 2021 · Peer-reviewed · PMID 34827486
  2. [2]Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposureUribe PM, Kawas LH, Harding JW, Coffin AB · Frontiers in Cellular Neuroscience · 2015 · Peer-reviewed · PMID 25674052

How to track Dihexa doses

Dihexa is tracked as a protocol rather than a single reminder: a vial with a concentration, a schedule that may be titrated or cycled, and a rotation of injection sites. Here is the record that keeps all three consistent.

  1. 1

    Record the vial and concentration

    Log the vial strength and the volume of bacteriostatic water you added so Dihexa is stored as a concentration rather than a guess. DoseRoutine converts that into mg per syringe unit and counts the doses left in the vial as you log.

  2. 2

    Set the schedule, not just a reminder

    Enter the dose in mg and the frequency (typical timing: morning). Cycled protocols get a start and end date so the history stays accurate when Dihexa comes out of the routine.

  3. 3

    Rotate and log the injection site

    Pick the site at the moment you log the dose. The site map shows what you used last and how recently, which is the part that drifts fastest when two compounds run on different frequencies.

  4. 4

    Log adherence, not intentions

    Mark each dose taken, skipped or delayed as it happens. Weeks of honest logs are what make an adherence rate or a trend line meaningful; retrospective guessing is not.

  5. 5

    Review against outcomes

    Review Dihexa alongside your logged metrics and any relevant blood work every few weeks before changing the dose, so the change is a response to data rather than to a good or bad day.

What to log each time

  • Dose in mg and the syringe units it worked out to
  • Vial: reconstitution date, concentration, doses remaining
  • Injection site and time
  • Any side effects in the 24 h after the dose
Reconstitution calculatorCompare dose tracking appsvs. Peptide TrackerTrack Dihexa in DoseRoutine

References & Evidence

Sources on this page that document Dihexa dosing, timing and safety.

  1. [1]National Center for Biotechnology Information View source

Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.

What is Dihexa studied for?

Brain & Cognition

What is Dihexa?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.

Dihexa, also known by its chemical name N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is a synthetic peptide that has garnered attention for its potential neurotrophic effects. It was developed as an analog of angiotensin IV, a compound naturally occurring in the body. Research on Dihexa primarily focuses on its ability to promote the formation of new synaptic connections (synaptogenesis) and enhance the function of existing ones. This peptide is orally bioavailable and has been studied in various preclinical models to understand its impact on cognitive processes, memory, and neurodegenerative conditions. As a synthetic compound, it is not found naturally in foods or traditional supplements.

What does the research say about Dihexa?

Tap a section to expand.

Dihexa's primary mechanism of action is believed to involve its interaction with the hepatocyte growth factor (HGF) system. HGF is a potent growth factor with neurotrophic properties, meaning it supports the survival, growth, and differentiation of neurons. Dihexa is thought to bind to and activate the c-Met receptor, which is the receptor for HGF. By activating c-Met, Dihexa mimics and enhances the downstream signaling pathways that are typically stimulated by HGF. These pathways are crucial for promoting synaptogenesis, neuronal plasticity, and overall brain health. Additionally, Dihexa has been investigated for its ability to increase the number and strength of synaptic connections in areas of the brain critical for learning and memory. This mechanism distinguishes it from many other compounds aimed at cognitive enhancement, which often focus on neurotransmitter modulation. (Source: PubChem, DrugBank)

Source for this section: Sources for How does Dihexa work?: Jumps to this entry in the sources and references list at the end of the page.

Research into Dihexa's potential benefits centers on its neurotrophic and synaptogenic properties. Preclinical studies have explored its impact on various aspects of brain function: * **Cognitive Function:** Studies in animal models have suggested that Dihexa may improve learning and memory, including spatial memory and object recognition. These effects are attributed to its promotion of synaptic connections in areas like the hippocampus. (Source: PubChem) * **Neuroprotection:** There is interest in Dihexa's potential to protect neurons from damage and support their survival, particularly in conditions involving neuronal injury or degeneration. Its ability to activate the HGF/c-Met pathway is considered key to these neuroprotective effects. * **Synaptogenesis:** A core area of investigation is Dihexa's demonstrated capacity in laboratory settings to promote the formation of new synapses, which are critical for brain plasticity and the establishment of new memories. (Source: DrugBank) It is important to note that these potential benefits are derived primarily from preclinical studies. Clinical trials in humans are necessary to confirm these effects and establish the safety and efficacy of Dihexa for human use.

Evidence for Dihexa's effects primarily comes from in vitro (cell culture) and in vivo (animal model) studies. For instance, research published in the _Journal of Pharmacology and Experimental Therapeutics_ and other scientific journals has explored Dihexa's impact on cognitive function in animal models of cognitive impairment. These studies have reported improvements in memory and learning tasks following Dihexa administration. Furthermore, laboratory experiments have demonstrated its ability to promote synaptogenesis and neurite outgrowth in neuronal cell cultures. While these preclinical findings are promising, it is crucial to recognize that the scientific community is still in the early stages of understanding Dihexa's full potential and safety profile in humans. As of now, there are no large-scale human clinical trials establishing its efficacy for any medical condition. (Source: PubChem, DrugBank)

Due to the limited human clinical data on Dihexa, the full spectrum of potential side effects is not well-established. Animal studies have generally reported it to be well-tolerated at investigated doses. However, as with any compound that affects powerful biological pathways like growth factors and neuronal plasticity, there is a theoretical potential for various effects. These could include, but are not limited to, alterations in cell growth or differentiation in areas beyond the brain, or unintended consequences related to enhanced synaptic activity. Without human clinical trials, specific side effects, their frequency, or severity cannot be definitively stated. This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.

Given the nascent stage of research into Dihexa, particularly in humans, several warnings are crucial. The long-term effects of Dihexa use are unknown. Its impact on various physiological systems beyond the brain has not been thoroughly investigated. Individuals with pre-existing neurological conditions, psychiatric disorders, or other chronic health issues should exercise extreme caution, as the interaction of Dihexa with these conditions or their treatments is unstudied. Its potential to influence cell growth pathways raises theoretical concerns that require further investigation. Due to the lack of extensive safety data, use by pregnant or breastfeeding individuals is strongly discouraged. This compound is not approved for any medical use by regulatory bodies like the FDA or EMA. This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.

Specific contraindications for Dihexa have not been formally established due to the absence of human clinical trials and regulatory approval. However, based on its proposed mechanism of action involving growth factors and neuronal plasticity, theoretical contraindications could include: a history of cancer or pre-cancerous conditions, as modulating growth factor pathways could theoretically influence cell proliferation; individuals with unstable neurological conditions where altered neuronal connectivity could be detrimental; or anyone undergoing treatment with medications that affect similar pathways. Absolute contraindications for specific patient populations are unknown due to lack of research. This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.

Without comprehensive human clinical trial data, definitive information on compounds that should not be mixed with Dihexa is unavailable. However, due to its proposed mechanism of activating growth factor pathways, it would be prudent to avoid combining it with other compounds that significantly alter neuronal growth, plasticity, or cell proliferation pathways without explicit medical supervision. This particularly includes other research compounds or drugs that influence HGF/c-Met signaling or general neurotrophic factor activity. Combining Dihexa with central nervous system stimulants, depressants, or other psychoactive compounds could theoretically lead to unpredictable interactions, as its effects on brain function are still largely uncharacterized in humans. This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.

While Dihexa's typical timing in research settings is often in the morning, specific optimal timing for human use is not established due to the lack of clinical trials. The half-life of Dihexa is approximately 10 hours, suggesting that a single daily administration could be sufficient to maintain consistent levels, though this is speculative without human pharmacokinetic data. Dihexa can be taken with or without food, as its oral bioavailability does not appear to be significantly affected by food intake. For any user-directed administration, dosing and timing *must* be set by a licensed clinician. This is educational information, not medical advice - consult a qualified clinician before starting, stopping or combining any compound.

Source for this section: Sources for When should you take Dihexa?: Jumps to this entry in the sources and references list at the end of the page.

What interacts with Dihexa?

Documented interactions for Dihexa: the other compound, the severity and confidence of the interaction, what happens, and what to do.
Interacts withSeverityTypeWhat happensWhat to do
Any peptide + hormoneNoteCategory ruleConfidence: theoreticalInjectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.Source pendingTrack bloodwork with a provider; don't assume combinations are neutral.

Frequently asked questions about Dihexa

Dihexa is a research peptide. It is also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide. The references summarized come from NIH and PubMed records, FDA labeling where it exists, and Mayo Clinic patient material.

Dihexa is commonly discussed in the context of supporting brain. Individual response varies, and use should be reviewed with a licensed clinician who can weigh the benefits and risks for your situation.

For Dihexa, it is typically taken in the morning. Always follow the specific dose your clinician or the product label prescribes.

Dihexa carries potential side effects and drug interactions, documented in NIH, Mayo Clinic, and FDA label sources. Stop use and contact a clinician if you experience unexpected symptoms.

As a peptide, Dihexa can overlap with other supplements, prescription medicines, hormones and peptides. Because Dihexa is usually taken in the morning, most avoidable conflicts come from what else lands in that same window. Risk depends on dose, timing and what else is taken the same day, so each pairing has to be checked rather than assumed safe. The free checker at https://doseroutine.com/interaction-checker covers Dihexa with no sign-up.

Whether Dihexa fits alongside testosterone replacement therapy depends on the protocol — dose, ester and ancillaries such as HCG or anastrozole — and on current bloodwork. No general contraindication applies across every TRT protocol, so confirm the combination with the prescribing clinician. See the free TRT interaction reference: https://doseroutine.com/trt-supplement-interactions

"Peptides" is not one category — healing peptides, GLP-1 agonists, growth-hormone secretagogues and melanocortins each behave differently next to Dihexa. Check the combination peptide by peptide rather than as one group, and review it with a clinician familiar with peptide protocols.

Published frequency for Dihexa varies by protocol and formulation, so the label or prescription is what sets it. It is typically taken in the morning. Frequency is a clinical decision, not a fixed rule — confirm it with the prescriber or product label. Comparison of apps that keep a schedule like this: https://doseroutine.com/best-dose-tracking-apps

The effect of a missed dose of Dihexa depends on the protocol and formulation you are on. Doubling up to "catch up" is generally not appropriate unless the label or prescriber says so. Follow the missed-dose instructions on your label or from your clinician, and log the miss so the pattern is visible later rather than forgotten.

For Dihexa the useful record is the dose, the time it was actually taken, and what else was taken in the same window. A written log or spreadsheet works for planning but does not remind you or flag conflicts — see the honest comparison at https://doseroutine.com/vs/spreadsheet and the wider roundup at https://doseroutine.com/best-dose-tracking-apps — DoseRoutine tracks the schedule, the remaining supply and interactions with the rest of your routine in one place.

No regulator has approved dihexa for any indication, and there are no published completed human clinical trials establishing a safe exposure. Everything circulating about human use comes from self-experimentation reports rather than controlled data, so both effectiveness and safety in people are unestablished. This is educational information, not medical advice.

In rodent and cell studies dihexa augments hepatocyte growth factor signaling at the c-Met receptor, which increased dendritic spine and synapse formation and improved performance in memory tasks in impaired animals. These are preclinical findings in models, and effects in animal cognition models frequently fail to reproduce in humans. This is educational information, not medical advice.

The c-Met pathway it amplifies is also involved in cell proliferation and is implicated in several cancers, so chronic activation is a theoretical oncological concern that no human study has ruled out. On top of that, research-chemical supply means no purity, sterility or content verification. This is educational information, not medical advice.

Sources cited on this page

Specific documents referenced by the numbered markers above. Each number matches the marker in the text.

  1. PubChem CID 129010512(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/129010512

Verify at

Publisher search links for Dihexa. These are places to check the information — they are not citations, so they are not numbered.

DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.

What is the short answer on Dihexa?

Plain-text summary, safe to quote verbatim:

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an experimental small peptide derived from angiotensin IV, studied in preclinical models for its ability to promote synapse formation through the hepatocyte growth factor / c-Met pathway. Interest comes from rodent work in Alzheimer's and Parkinson's models.
Source: DoseRoutine — https://doseroutine.com/library/dihexa

Cite this page

Using this in an article, AI answer, or research note? Please attribute:

DoseRoutine. (2026). Dihexa — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/dihexa
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