medicationPrescription only (US)Bupropion is an approved medicine; the cited literature reports trial outcomes, not dosing advice.
BupropionBenefits, Dosage & Interactions
Also known as: Wellbutrin, Zyban
Bupropion is an antidepressant medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD), and as an aid to smoking cessation. It is marketed under various brand names, including Wellbutrin and Zyban.
Researched by DoseRoutine R&D TeamReviewed for accuracy by Nicholas Alexander, RSELast updated
Evidence: Strong — 617 human randomized trials and regulatory approval on file.
Evidence strengthStrong · 4/4
PreclinicalStrong human evidence
617 human randomized trials and regulatory approval on file.
Plasma half-life
~21 h
Typical timing
morning
Default unit
mg
What published protocols report
Ranges documented in the literature, shown for reference. DoseRoutine does not recommend an amount — your prescriber or the product label sets the dose.
Reported for Bupropion in the cited sources. Published ranges are not dosing advice.
References & evidence
Documents the Bupropion entry is written from. Each number matches an inline marker above.
- [1]Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder: A Phase 3 Randomized Clinical Trial (GEMINI)Iosifescu DV, Jones A, O'Gorman C, et al. · J Clin Psychiatry · 2022 · Peer-reviewed · PMID 35649167
- [2]Aripiprazole or Bupropion Augmentation Versus Switching to Bupropion in Treatment-Resistant Depression: A Risk-Benefit AnalysisMeyerson WU, Ross EL, Kennedy CJ, Hoyle RH, Chhatwal J, Wang PS, Smoller JW · The Journal of Clinical Psychiatry · 2025 · Peer-reviewed · PMID 41004167
How to track Bupropion doses
Tracking Bupropion well takes four fields and a habit. Here is what to record so the log is still useful in three months.
- 1
Add the dose and unit
Log Bupropion with its dose in mg so totals stay comparable over time — including days when you split the dose or skip it.
- 2
Set the time of day and food rule
Typical timing is morning. Reminders fire at that time and can export to your calendar.
- 3
Check it against the rest of the stack
Run Bupropion through the interaction checker against everything else in the routine — supplements, peptides, hormones and prescriptions — before it becomes a daily habit.
- 4
Log adherence, not intentions
Mark each dose taken, skipped or delayed as it happens. Weeks of honest logs are what make an adherence rate or a trend line meaningful; retrospective guessing is not.
- 5
Review against outcomes
With a reported half-life around 21 h, effects and timing shifts show up over days rather than instantly. Review Bupropion alongside your logged metrics and any relevant blood work every few weeks before changing the dose.
What to log each time
- Dose in mg
- Time of day
- Taken / skipped / delayed
- Any side effects or notable changes
References & Evidence
Sources on this page that document Bupropion dosing, timing and safety.
- [1]National Center for Biotechnology Information View source
Educational information only — not medical advice. Dose ranges vary by person, indication and prescriber.
What is Bupropion?Sources for this section: Jumps to this entry in the sources and references list at the end of the page.
Bupropion is an antidepressant medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD), and as an aid to smoking cessation. It is marketed under various brand names, including Wellbutrin and Zyban. Unlike many other antidepressants, bupropion does not primarily affect serotonin levels; instead, its mechanism involves norepinephrine and dopamine. This distinct pharmacological profile is thought to contribute to its specific therapeutic effects and a different side effect spectrum compared to selective serotonin reuptake inhibitors (SSRIs).
Bupropion is generally taken orally, typically once or twice daily depending on the formulation (immediate-release, sustained-release, or extended-release). Its use requires careful monitoring, particularly due to dose-dependent risks of seizures. The medication's role in smoking cessation is attributed to its effects on neurotransmitters that can reduce cravings and withdrawal symptoms. In some cases, bupropion has also been explored off-label for other conditions, such as attention-deficit/hyperactivity disorder (ADHD) and obesity, although these uses are not FDA-approved. The half-life of bupropion is approximately 21 hours, necessitating consistent dosing to maintain therapeutic levels. It can be taken with or without food. Bupropion is not a controlled substance.
What does the research say about Bupropion?
Tap a section to expand.
Bupropion's primary mechanism of action involves the reuptake inhibition of norepinephrine and dopamine in the brain. This means it blocks the reabsorption of these neurotransmitters into nerve cells, leading to increased concentrations in the synaptic cleft, the space between neurons. This increase in available norepinephrine and dopamine is thought to be responsible for its antidepressant and anti-smoking effects.
Specifically:
* **Norepinephrine Reuptake Inhibition:** Norepinephrine is a neurotransmitter involved in alertness, focus, and mood. By inhibiting its reuptake, bupropion can enhance its signaling, which may contribute to improved mood and energy levels.
* **Dopamine Reuptake Inhibition:** Dopamine plays a crucial role in reward, motivation, and pleasure pathways. Increasing dopamine levels may help alleviate symptoms of depression, improve anhedonia (inability to feel pleasure), and reduce nicotine cravings, as nicotine also affects dopaminergic pathways.
Unlike many conventional antidepressants, bupropion has minimal effects on serotonin reuptake. This unique profile is often cited as a reason for its different side effect profile, potentially causing fewer sexual side effects and less weight gain compared to SSRIs. However, it is noteworthy that bupropion is metabolized in the liver to several active metabolites, including hydroxybupropion, which also contribute to its pharmacological activity and extend its duration of action. The exact neural circuits and molecular interactions fully responsible for bupropion's therapeutic efficacy are still areas of ongoing research (PubChem, DrugBank).
Source for this section: Sources for How does Bupropion work?: Jumps to this entry in the sources and references list at the end of the page.
Bupropion offers several established benefits, primarily in the treatment of mood disorders and smoking cessation.
* **Major Depressive Disorder (MDD):** FDA-approved for the treatment of MDD, bupropion has been shown to alleviate symptoms such as low mood, loss of interest, low energy, and difficulty concentrating. Its unique mechanism, which largely spares serotonin, can be an advantage for individuals who experience adverse effects from SSRIs, particularly sexual dysfunction or weight gain (FDA label).
* **Seasonal Affective Disorder (SAD):** Bupropion extended-release is FDA-approved for the prevention of seasonal affective disorder. It is typically started in the autumn before the onset of depressive symptoms and continued through the winter season (FDA label).
* **Smoking Cessation:** Bupropion sustained-release is FDA-approved as an aid to smoking cessation. It is thought to reduce nicotine cravings and withdrawal symptoms, making it easier for individuals to quit smoking. Its efficacy in this context is widely recognized, often used as part of a comprehensive cessation program (NIH ODS, Cochrane).
* **Potential for Weight Management:** While not its primary indication for weight loss, bupropion's effects on dopamine and norepinephrine can sometimes lead to appetite reduction and modest weight loss. This can be a beneficial side effect for individuals with depression who have also experienced weight gain or are struggling with obesity (Mayo Clinic). A combination product of bupropion and naltrexone is FDA-approved for chronic weight management in certain patients.
* **Less Sexual Dysfunction:** Compared to many other antidepressants, bupropion is associated with a lower incidence of sexual side effects, such as decreased libido, delayed ejaculation, or anorgasmia. This can be an important consideration for patients for whom these side effects are particularly bothersome or lead to medication non-adherence (Mayo Clinic).
The efficacy of bupropion across its approved indications is supported by numerous clinical trials and systematic reviews.
For major depressive disorder (MDD), multiple randomized controlled trials have demonstrated bupropion's superiority to placebo and non-inferiority or comparable efficacy to some other antidepressant classes (e.g., SSRIs) in reducing depressive symptoms. Data from the STAR*D study (Sequenced Treatment Alternatives to Relieve Depression), a large-scale effectiveness study funded by the National Institute of Mental Health, provided insights into bupropion's role as a monotherapy and as an augmentation strategy for patients with MDD who do not respond to initial treatment with an SSRI (NIH ODS).
In the context of seasonal affective disorder (SAD), clinical trials have shown that prophylactic treatment with bupropion extended-release significantly reduces the incidence of depressive episodes compared to placebo. These studies typically evaluate symptom severity and disease recurrence over the winter months (FDA label).
For smoking cessation, a comprehensive Cochrane review of 115 trials concluded that bupropion significantly increases long-term smoking abstinence rates compared to placebo. The review indicated that bupropion's efficacy is comparable to that of varenicline and nicotine replacement therapy, strengthening its position as a first-line pharmacotherapy for smoking cessation (Cochrane Library). Studies have explored its mechanism in reducing cravings and withdrawal symptoms, linking these effects to its impact on dopamine pathways (NIH ODS).
Furthermore, research continues to explore bupropion's precise mechanisms and potential off-label uses. Evidence regarding its effects on weight, attention-deficit/hyperactivity disorder (ADHD), and chronic pain is emerging, though these uses currently lack full FDA approval and require more robust evidence for widespread clinical recommendation (DrugBank).
Like all medications, bupropion can cause side effects. The most common side effects are generally mild to moderate and may diminish over time as the body adjusts to the medication. However, some side effects can be serious and require immediate medical attention.
Common side effects (occurring in 10% or more of patients, per FDA label):
* Dry mouth
* Nausea
* Insomnia
* Dizziness
* Anxiety
* Constipation
* Tremor
* Pharyngitis (sore throat)
* Sweating
Less common but notable side effects (per FDA label):
* Headache
* Agitation
* Tachycardia (increased heart rate)
* Blurred vision
* Rash
* Weight loss (often a desired effect in some patients, but can be undesired)
Serious side effects that require immediate medical attention include:
* **Seizures:** This is the most serious and dose-dependent risk. The risk increases significantly with higher doses, previous seizure history, head trauma, central nervous system tumors, or abrupt discontinuation of benzodiazepines or alcohol.
* **Neuropsychiatric symptoms:** New or worsening anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (restlessness), hypomania, mania, and suicidal ideation or behavior.
* **Hypertension (high blood pressure):** Bupropion can cause elevations in blood pressure, sometimes severe, which may require treatment. Blood pressure should be monitored regularly.
* **Allergic reactions:** Hives, rash, itching, fever, swollen lymph nodes, joint pain, or swelling of the face, lips, tongue, or throat.
* **Angle-closure glaucoma:** Rarely, bupropion can cause dilation of the pupil, potentially triggering an angle-closure glaucoma attack in susceptible individuals.
It is crucial to promptly report any concerning or severe side effects to a healthcare provider. This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Bupropion carries several important warnings and precautions that necessitate careful consideration before and during treatment.
* **Seizure Risk:** Bupropion is associated with a dose-dependent risk of seizures. This risk increases significantly with doses above 450 mg/day (for immediate-release formulations or equivalent extended-release), in individuals with a history of seizures, certain medical conditions (e.g., severe head injury, AV malformation, CNS tumor, severe stroke), or with abrupt discontinuation of benzodiazepines or alcohol, or concurrent use of other seizure-lowering agents. It is contraindicated in patients with a seizure disorder. (FDA label)
* **Neuropsychiatric Reactions, including Suicidality:** Antidepressants, including bupropion, can increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18-24) with major depressive disorder and other psychiatric disorders. Close monitoring for clinical worsening, suicidality, or unusual changes in behavior is essential, especially during initial treatment and dose changes. Families and caregivers should be advised of the need for close observation. (FDA label)
* **Activation of Mania/Hypomania:** Bupropion can precipitate manic or hypomanic episodes in patients with Bipolar Disorder. It should be used with caution in patients with a history of mania or hypomania, and generally should not be used in patients with current or recent mania. (FDA label)
* **Hypertension:** Bupropion can cause increases in blood pressure, sometimes severe, necessitating monitoring of blood pressure before and during treatment. The risk may be higher in individuals with pre-existing hypertension or when used with nicotine replacement therapy. (FDA label)
* **Angle-Closure Glaucoma:** Bupropion can cause mydriasis (pupil dilation), which may trigger an acute angle-closure glaucoma attack in individuals with anatomically narrow angles without a patent iridectomy. (FDA label)
* **Hepatic and Renal Impairment:** Bupropion is extensively metabolized in the liver and excreted by the kidneys. Patients with hepatic or renal impairment may require reduced doses and careful monitoring due to potential accumulation of bupropion and its metabolites. (FDA label)
* **Neuropsychiatric Symptoms and Suicide Risk during Smoking Cessation (Zyban specific):** Serious neuropsychiatric events, including depression, suicidal ideation, suicide attempt, and completed suicide have been reported in patients taking bupropion for smoking cessation. These events have occurred in patients with and without pre-existing psychiatric disease. Patients should be observed for these symptoms. (FDA label)
This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Bupropion is contraindicated in specific situations due to significant safety risks. These contraindications are critical to respect to prevent severe adverse outcomes.
* **Seizure Disorder:** Bupropion is absolutely contraindicated in individuals with a current or past diagnosis of a seizure disorder. The medication significantly lowers the seizure threshold, increasing the risk of seizures. (FDA label)
* **History of Anorexia Nervosa or Bulimia Nervosa:** Bupropion is contraindicated in patients with a current or prior diagnosis of anorexia nervosa or bulimia nervosa. These eating disorders are associated with an increased risk of electrolyte imbalances and seizures, which bupropion would exacerbate. (FDA label)
* **Abrupt Discontinuation of Alcohol, Benzodiazepines, Barbiturates, or Antiepileptic Drugs:** Initiating bupropion immediately after abruptly stopping alcohol or sedatives (like benzodiazepines or barbiturates) or antiepileptic drugs is contraindicated. Withdrawal from these substances can lower the seizure threshold, and combining this with bupropion's seizure-lowering effect significantly increases seizure risk. (FDA label)
* **Concurrent Use with MAOIs:** Bupropion is contraindicated in patients currently receiving or who have recently (within 14 days) received monoamine oxidase inhibitors (MAOIs). Concomitant use can lead to a hypertensive crisis and other severe reactions. Similarly, at least 14 days should elapse between discontinuing bupropion and starting an MAOI. (FDA label)
* **Hypersensitivity to Bupropion or its Components:** Individuals with known hypersensitivity or allergic reactions to bupropion or any of the excipients in the formulation should not take the medication. (FDA label)
This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Interactions between bupropion and other medications can alter the effects of either compound, potentially leading to increased side effects or reduced efficacy. Careful consideration and professional guidance are essential.
* **Monoamine Oxidase Inhibitors (MAOIs):** Bupropion should not be used concurrently with or within 14 days of discontinuing MAOIs (e.g., phenelzine, tranylcypromine, selegiline). This combination can lead to a hypertensive crisis and other severe adverse reactions. Conversely, at least 14 days should pass after discontinuing bupropion before starting an MAOI. (FDA label)
* **Other Bupropion-Containing Products:** Do not take bupropion if you are already taking any other medication that contains bupropion (e.g., Wellbutrin, Zyban, Aplenzin, Forfivo XL) or a combination product that includes bupropion (e.g., Contrave). Taking multiple bupropion-containing products significantly increases the risk of seizures and other dose-dependent adverse effects. (FDA label)
* **Alcohol or Sedative-Hypnotics (e.g., Benzodiazepines, Barbiturates):** Abrupt discontinuation of alcohol or sedatives while taking bupropion can significantly lower the seizure threshold and increase the risk of seizures. It is also generally advised to minimize or avoid alcohol consumption while on bupropion due to potential CNS depressant effects and exacerbation of neuropsychiatric symptoms. (FDA label)
* **Drugs that Lower Seizure Threshold:** Concomitant use of bupropion with other medications that can lower the seizure threshold (e.g., tricyclic antidepressants, antipsychotics, systemic corticosteroids, theophylline, tramadol) can increase the risk of seizures. Caution and dose adjustments may be necessary. (FDA label)
* **CYP2D6 Substrates and Inhibitors:** Bupropion and its main metabolite, hydroxybupropion, are inhibitors of the cytochrome P450 2D6 (CYP2D6) enzyme. This means bupropion can affect the metabolism of drugs primarily cleared by CYP2D6, potentially increasing their levels and risk of toxicity. Examples include SSRIs (e.g., paroxetine, fluoxetine, sertraline), tricyclic antidepressants (e.g., imipramine, desipramine), beta-blockers (e.g., metoprolol), antiarrhythmics (e.g., propafenone, flecainide), and antipsychotics (e.g., haloperidol, risperidone). Conversely, strong CYP2D6 inhibitors (e.g., quinidine, ritonavir) can increase bupropion levels. (FDA label, DrugBank)
* **Dopaminergic Drugs:** Bupropion can potentiate the effects of dopaminergic drugs. Co-administration with levodopa or amantadine should be done with extreme caution, as it may result in increased central nervous system adverse effects, such as restlessness, agitation, tremor, and psychosis. (FDA label)
* **Nicotine Transdermal Systems:** When bupropion is used for smoking cessation, concurrent use of nicotine transdermal systems requires careful monitoring of blood pressure, as significant increases in blood pressure have been observed. (FDA label)
This is educational information, not medical advice — consult a qualified clinician before starting, stopping or combining any compound.
Bupropion is typically taken once or twice daily, depending on the specific formulation (immediate-release, sustained-release, or extended-release). Oral sustained-release and extended-release formulations are designed to be taken once daily in the morning to minimize the risk of insomnia associated with evening dosing. Immediate-release formulations are usually dosed more frequently, such as two or three times a day, with the last dose not too close to bedtime.
* **Typical Timing:** Most commonly, bupropion (especially extended-release forms) is taken in the morning. This timing helps to mitigate potential sleep disturbances, as bupropion can be stimulating. (FDA label)
* **With or Without Food:** Bupropion can be taken with or without food. Food does not significantly alter its absorption. However, taking it with food might help reduce gastrointestinal upset for some individuals. (FDA label)
* **Consistency:** To maintain stable drug levels in the body and maximize therapeutic effects, it is important to take bupropion consistently at the same time each day as prescribed. (Mayo Clinic)
* **Swallowing Instructions:** Bupropion tablets, particularly sustained-release and extended-release formulations, should be swallowed whole. They should not be crushed, chewed, or divided, as this can lead to a rapid release of the drug, increasing the risk of side effects, including seizures. (FDA label)
Source for this section: Sources for When should you take Bupropion?: Jumps to this entry in the sources and references list at the end of the page.
What interacts with Bupropion?
| Interacts with | Severity | Type | What happens | What to do |
|---|---|---|---|---|
| Any supplement + medication | Note | Category ruleConfidence: theoretical | Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).Source pending | Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist. |
| Any vitamin + medication | Note | Category ruleConfidence: theoretical | Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).Source pending | Specific pairs are checked against a licensed source; confirm with your provider. |
| Amantadine | Caution | Compound pairConfidence: theoretical | Both lower seizure threshold and are dopaminergic. Combined use raises seizure and CNS-stimulation risk.Source pending | Use together only under a prescriber. Report tremor, agitation, or any seizure activity immediately. |
Frequently asked questions about Bupropion
- A: Bupropion primarily affects dopamine and norepinephrine, whereas SSRIs (selective serotonin reuptake inhibitors) primarily affect serotonin. This difference in mechanism often leads to different side effect profiles, with bupropion potentially causing fewer sexual side effects and less weight gain than SSRIs, but a higher risk of seizures.
- A: While not its primary approved indication for weight loss, bupropion can sometimes cause modest weight loss as a side effect. It is also an ingredient in a combination medication (with naltrexone) that is FDA-approved for chronic weight management in certain individuals.
- A: If you miss a dose, do not take the missed dose if it is close to the time for your next scheduled dose. Never take a double dose to make up for a missed one, as this significantly increases the risk of seizures. Contact your healthcare provider for specific guidance.
- A: Like many antidepressants, bupropion does not typically work immediately. It may take several weeks (e.g., 2-4 weeks) or even longer to experience the full therapeutic benefits for depression or for smoking cessation. Consistency in taking the medication is key.
Bupropion is a medication, and interactions are possible with prescriptions, hormones, peptides and other supplements in the same routine. Because Bupropion is usually taken in the morning, most avoidable conflicts come from what else lands in that same window. With a reported plasma half-life near 21 hours, separating doses can change the picture as much as removing one. Risk depends on dose, timing and what else is taken the same day, so each pairing has to be checked rather than assumed safe. The free checker at https://doseroutine.com/interaction-checker covers Bupropion with no sign-up.
Combining a medication like Bupropion with TRT is usually a question of labs rather than a blanket yes or no: the ester, injection interval and any aromatase inhibitor all change the answer. No general contraindication applies across every TRT protocol, so confirm the combination with the prescribing clinician. See the free TRT interaction reference: https://doseroutine.com/trt-supplement-interactions
Each peptide class carries its own profile against Bupropion: a healing peptide raises different questions than a GLP-1 agonist or a growth-hormone secretagogue. Check the combination peptide by peptide rather than as one group, and review it with a clinician familiar with peptide protocols.
With a plasma half-life near 21 hours, once-daily dosing is the usual pattern for Bupropion. It is typically taken in the morning. Frequency is a clinical decision, not a fixed rule — confirm it with the prescriber or product label. Comparison of apps that keep a schedule like this: https://doseroutine.com/best-dose-tracking-apps
For Bupropion the useful record is the dose, the time it was actually taken, and what else was taken in the same window. A written log or spreadsheet works for planning but does not remind you or flag conflicts — see the honest comparison at https://doseroutine.com/vs/spreadsheet and the wider roundup at https://doseroutine.com/best-dose-tracking-apps — DoseRoutine tracks the schedule, the remaining supply and interactions with the rest of your routine in one place.
Which studies looked at Bupropion?
Peer-reviewed research indexed in PubMed. Each entry links to the original record.
- 1.Bupropion and Anxiety: A Brief Review(opens PubMed in a new tab)Hum Psychopharmacol · 2025 · PMID 40958494 · https://pubmed.ncbi.nlm.nih.gov/40958494/
- 2.Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder: A Phase 3 Randomized Clinical Trial (GEMINI)(opens PubMed in a new tab)J Clin Psychiatry · 2022 · PMID 35649167 · https://pubmed.ncbi.nlm.nih.gov/35649167/
- 3.Bupropion and Naltrexone in Methamphetamine Use Disorder(opens PubMed in a new tab)N Engl J Med · 2021 · PMID 33497547 · https://pubmed.ncbi.nlm.nih.gov/33497547/
- 4.Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial(opens PubMed in a new tab)Lancet · 2016 · PMID 27116918 · https://pubmed.ncbi.nlm.nih.gov/27116918/
Sources cited on this page
Specific documents referenced by the numbered markers above. Each number matches the marker in the text.
- PubChem CID 62884(opens in a new tab)National Center for Biotechnology Information · pubchem.ncbi.nlm.nih.gov/compound/62884
Verify at
Publisher search links for Bupropion. These are places to check the information — they are not citations, so they are not numbered.
- FDA-approved labeling (DailyMed)(publisher search, opens in a new tab)U.S. Food and Drug Administration · publisher search
- NIH Office of Dietary Supplements(publisher search, opens in a new tab)National Institutes of Health · publisher search
- MedlinePlus(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- Mayo Clinic(publisher search, opens in a new tab)Mayo Clinic · publisher search
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
- DrugBank(publisher search, opens in a new tab)DrugBank Online · publisher search
- PubMed literature search(publisher search, opens in a new tab)National Library of Medicine · publisher search
- Wikipedia entry(publisher search, opens in a new tab)Wikipedia · publisher search
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician. How we source and review this information.
What is the short answer on Bupropion?
Plain-text summary, safe to quote verbatim:
Bupropion is an antidepressant medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD), and as an aid to smoking cessation. It is marketed under various brand names, including Wellbutrin and Zyban.
Source: DoseRoutine — https://doseroutine.com/library/bupropion
Cite this page
Using this in an article, AI answer, or research note? Please attribute:
DoseRoutine. (2026). Bupropion — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/bupropion
What compounds are similar to Bupropion?
Others in the medication category or studied for the same goals.