Can you take Sertraline and St John's Wort together?
Not together — this combination should be avoided.
Sertraline and St John's Wort should not be taken together without medical supervision.
Why these two interactSources for why these two interact: Jumps to this entry in the sources and references list at the end of the page.
St John's Wort has serotonergic activity and induces CYP3A4, altering SSRI levels.
Inferred from a shared mechanism, not documented for this specific pair. The same explanation is applied to other combinations that work the same way.
What to do about itSources for what to do about it: Jumps to this entry in the sources and references list at the end of the page.
Avoid combining.
TimingSources for timing: Jumps to this entry in the sources and references list at the end of the page.
Separating the doses does not solve this one. The concern is the combined effect in the body, not absorption timing, so spacing them out is not a workaround.
The two items in this pair
Sertraline
- Category:
- medication
- Typical timing:
- morning
- With food:
- either
- Half-life:
- 26 h
Check your whole routine, not just this pair
One pair rarely tells the whole story. DoseRoutine checks every combination in your stack at once — supplements, TRT, peptides, GLP-1s and prescriptions — and schedules the doses so timing conflicts like this one are handled automatically.
Frequently asked
Sources cited on this page
Specific documents referenced by the numbered markers above.
- The serotonin syndrome(opens in a new tab)PubMed — National Library of Medicine · pubmed.ncbi.nlm.nih.gov/15784664/
- Serotonin syndrome — a focused review(opens in a new tab)PubMed — National Library of Medicine · pubmed.ncbi.nlm.nih.gov/37309284/
- Nardil (phenelzine sulfate) — FDA prescribing information(opens in a new tab)DailyMed — U.S. National Library of Medicine · dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
Verify at
This assessment is mechanism-based. These publisher search links let you check it against the current evidence — they are not citations, so they are not numbered.
- PubMed: Sertraline + St John's Wort(publisher search, opens in a new tab)National Library of Medicine · publisher search
- DailyMed label: Sertraline(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- DailyMed label: St John's Wort(publisher search, opens in a new tab)U.S. National Library of Medicine · publisher search
- Cochrane Library(publisher search, opens in a new tab)Cochrane · publisher search
Related combinations
Educational information only, not medical advice. DoseRoutine does not diagnose or treat. Talk to your prescriber before starting, stopping or combining anything — especially if you take prescription medication or are pregnant or breastfeeding.