SS-31, also known as Elamipretide or Bendavia, is a synthetic tetrapeptide that has garnered significant interest for its targeted action on mitochondria. Specifically, SS-31 interacts with cardiolipin, a phospholipid found in the inner mitochondrial membrane, which is crucial for mitochondrial health and function. This interaction is believed to stabilize the inner mitochondrial membrane and protect against oxidative damage.
The peptide's structure, D-Arg-Dmt-Lys-Phe-NH2, allows it to readily cross biological membranes, including the blood-brain barrier, and accumulate within the mitochondria. This selective targeting is central to its proposed mechanisms of action in mitigating mitochondrial dysfunction, which is implicated in various age-related diseases and conditions of cellular stress. SS-31 is currently under investigation in clinical trials for several indications, reflecting its potential as a therapeutic agent (NIH Clinical Trials Registry, DrugBank).
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Known interactions
Category rule: peptide × hormone
Note
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
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