Serrapeptase, also known as serratiopeptidase, is a proteolytic enzyme derived from the *Enterobacteriaceae* bacterium, *Serratia marcescens*. This bacterium was originally found in the intestine of the silkworm, *Bombyx mori*, where the enzyme plays a role in dissolving the silkworm's cocoon. Serrapeptase has been investigated for its potential anti-inflammatory and pain-reducing properties, primarily due to its ability to break down proteins. It is available as a dietary supplement and has been studied for various conditions, including post-operative swelling, sinusitis, and carpal tunnel syndrome, though the extent of its efficacy and safety in all contexts is still under active research (PubChem). As an enterically-coated enzyme, it is designed to bypass stomach acid and be absorbed in the intestine, allowing it to exert systemic effects.
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Discuss with prescribing clinician; monitor for bruising, prolonged bleeding, and dose adjustments.
Sources referenced
* Examine.com
* PubChem (National Library of Medicine)
* MedlinePlus (National Library of Medicine)
* DrugBank
* Mayo Clinic
* NIH Office of Dietary Supplements (ODS)
* Cochrane Library (for enzyme reviews in general contexts)
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
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