Naltrexone is a medication primarily used in the management of alcohol dependence and opioid dependence. It functions as an opioid antagonist, meaning it blocks the effects of opioid drugs. In the context of alcohol dependence, it is thought to reduce the craving for alcohol and the rewarding effects of drinking, thereby supporting abstinence or reducing heavy drinking. For opioid dependence, it prevents euphoric effects and helps maintain abstinence after detoxification. Naltrexone is available in oral tablet form and as an extended-release injectable formulation (Vivitrol). The full dose typically refers to the oral administration, which generally involves a higher daily amount compared to low-dose naltrexone (LDN). It is important to note that naltrexone is not a narcotic and is not addictive. It does not produce a euphoric effect. Treatment with naltrexone should always be part of a comprehensive management program that includes counseling and psychosocial support, as emphasized by the Substance Abuse and Mental Health Services Administration (SAMHSA).
Deep dive
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Frequently asked
Sources referenced
* DrugBank
* U.S. Food and Drug Administration (FDA)
* National Institute on Alcohol Abuse and Alcoholism (NIAAA)
* Substance Abuse and Mental Health Services Administration (SAMHSA)
* Cochrane Database of Systematic Reviews
* PubMed (for various clinical studies and reviews)
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
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