MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a naturally occurring mitochondrial-derived peptide. Its analogue is a synthetic variation designed to mimic or enhance the actions of the endogenous peptide. MOTS-c is composed of 16 amino acids and has been identified as a key regulator of metabolic homeostasis, primarily through its influence on mitochondrial function. It is endogenously produced by mitochondria and enters circulation, acting as a signaling molecule. Research suggests it plays a role in glucose and fatty acid metabolism, insulin sensitivity, and cellular resilience to metabolic stress. The study of MOTS-c and its analogues often focuses on their potential therapeutic applications in metabolic disorders and age-related conditions. (Source: PubChem, NIH ODS)
Deep dive
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Known interactions
Category rule: peptide × hormone
Note
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
Frequently asked
Sources referenced
["PubChem","NIH Office of Dietary Supplements (ODS)","DrugBank","Examine.com","Mayo Clinic"]
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