GHRH (1-29), also known as Growth Hormone-Releasing Hormone (1-29) or Sermorelin, is a synthetic peptide fragment representing the first 29 amino acids of endogenous human Growth Hormone-Releasing Hormone (GHRH). It is classified as a secretagogue because it stimulates the pituitary gland to release its own growth hormone (GH) in a pulsatile, natural manner. Unlike direct administration of synthetic growth hormone, GHRH (1-29) encourages the body's natural physiological production and release of GH, which in turn can lead to increased levels of insulin-like growth factor-1 (IGF-1). The regulation of GH and IGF-1 is critical for many physiological processes, including body composition, metabolism, and cellular repair. Due to its short half-life and natural mode of action, GHRH (1-29) has been investigated for various applications, particularly those related to growth hormone deficiency, muscle development, and recovery processes. It is typically administered via subcutaneous injection.
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Deep dive
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Known interactions
Category rule: peptide × hormone
Note
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
Frequently asked
Sources referenced
* DrugBank
* FDA label (Sermorelin)
* MedlinePlus
* NIH Office of Dietary Supplements (ODS)
* PubChem
* PubMed (various research articles on GHRH, GH, and IGF-1 biology)
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