Semaglutide
8 sourced research updates tagged Semaglutide, newest first — what changed, what the evidence shows and what it means for how people run a protocol.
How much protein to eat while losing weight on a GLP-1
During weight loss on a GLP-1, a common practical target is roughly 1.2–1.6 g of protein per kilogram of body weight per day — higher than general adult requirements, because a substantial share of…
Taking metformin and a GLP-1 together: what actually changes
Metformin and GLP-1 receptor agonists are routinely prescribed together and there is no pharmacokinetic interaction requiring a dose change between them.
The first small-molecule GLP-1 pill is approved — what Foundayo changes
In April 2026 the FDA approved orforglipron (brand name Foundayo), the first small-molecule oral GLP-1 receptor agonist for chronic weight management.
The muscle problem with GLP-1s finally has trial data behind it
Up to 40% of the weight lost on GLP-1 therapy can come from lean mass, not fat. Two Phase 2 programs now show that this is partly fixable with drugs: the BELIEVE trial combined semaglutide with…
Is there a best time of day to take a weekly GLP-1?
Once-weekly semaglutide and tirzepatide can be injected at any time of day, with or without food, because their half-lives are measured in days rather than hours.
A simple injection-site rotation schedule for weekly injections
Approved weekly GLP-1 injections go subcutaneously into the abdomen, thigh or upper arm, and absorption is equivalent across those sites.
How long a reconstituted peptide really lasts in the fridge
Two separate clocks run on a reconstituted peptide vial kept in the fridge: chemical stability of the peptide in solution, and microbiological safety of a container you puncture repeatedly.
You missed your weekly GLP-1 dose — what the label actually says
For once-weekly semaglutide, the label says take the missed dose within 5 days of the scheduled day; past that, skip it and resume your normal schedule.