Menopause Supplement Interaction Checker
Check menopause supplements — black cohosh, soy isoflavones, vitex, DHEA, red clover, evening primrose — against HRT, birth control, thyroid medication, SSRIs, and everything else you take. Free for 7 days.
What this checks
- HRT interactions — estradiol, progesterone, testosterone.
- Birth control interactions — combined pills, mini-pill, IUD, ring.
- Thyroid medication timing — levothyroxine absorption conflicts.
- SSRI and mood-medication — serotonin and sedation risk.
- Blood thinner interactions — warfarin, apixaban, aspirin.
- Blood pressure medication — additive hypotension.
Menopause hubs and compound pages
FAQ
What is a menopause supplement interaction checker?
A tool that flags known conflicts between menopause-related supplements (black cohosh, soy isoflavones, red clover, vitex, DHEA, evening primrose) and the prescriptions women often take at the same time — estradiol HRT, progesterone, birth control, thyroid medication, SSRIs, blood thinners, and blood pressure drugs. DoseRoutine's checker uses named pharmacokinetic and receptor-level mechanisms for every flagged pair, not vague warnings.
Which menopause supplements interact with HRT?
St. John's wort (reduces estradiol levels via CYP3A4 induction), black cohosh (usually not combined for redundant coverage), DHEA (adds peripheral hormone conversion), vitex (modulates progesterone signalling), and high-dose soy isoflavones or red clover (weak additive ER activity). Non-hormonal options like maca, magnesium, and omega-3 don't meaningfully interact with HRT.
Which menopause supplements interact with birth control?
St. John's wort is the biggest issue — it induces CYP3A4 and can reduce ethinyl-estradiol enough to cause breakthrough bleeding or contraceptive failure. Most menopause-specific herbs (black cohosh, red clover, soy isoflavones) don't meaningfully reduce contraceptive efficacy but should still be checked pair-by-pair.
Which menopause supplements interact with thyroid medication?
Soy isoflavones reduce levothyroxine absorption if taken within 4 hours. Ashwagandha can push TSH down. Iron and calcium have the same absorption-timing issue. Always dose levothyroxine on an empty stomach and separate other supplements by 4 hours.
Are menopause supplements safe with SSRIs?
Most are compatible. St. John's wort with any SSRI is a serotonin-syndrome risk — do not combine. Black cohosh, soy isoflavones, and red clover have no meaningful SSRI interaction. Maca has small trials suggesting benefit for SSRI-induced low libido.
How do I use the DoseRoutine menopause interaction checker?
Open the interaction checker at doseroutine.com/interaction-checker, add every supplement and prescription you take (including HRT, birth control, thyroid medication), and DoseRoutine will show pairwise flags with mechanism and severity. Free for 7 days.
Open the DoseRoutine interaction checker
Add every supplement, HRT dose, and prescription — see the full pairwise safety picture in one view. Free for 7 days.
Open interaction checker