Trial phase

Phase 1

1 sourced research update tagged Phase 1, newest first — what changed, what the evidence shows and what it means for how people run a protocol.

Longevity2026-08-10

Longevity biology reached first-in-human: klotho mRNA and partial reprogramming

Two of the most-hyped ideas in aging biology moved into human testing in 2026. Life Biosciences received FDA clearance for a Phase 1 trial of ER-100, a gene therapy delivering the Yamanaka factors…

Klotho Yamanaka factors mRNA therapy Partial epigenetic reprogramming Phase 1

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Longevity biology reached first-in-human: klotho mRNA and partial reprogramming

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