Lisinopril is a medication belonging to a class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is primarily used to treat high blood pressure (hypertension), heart failure, and to improve survival after a heart attack. Lisinopril works by relaxing blood vessels, which allows blood to flow more easily and lowers blood pressure. It is available as an oral tablet and is a commonly prescribed medication. (Mayo Clinic, MedlinePlus)
Deep dive
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Known interactions
Compound-pair rule
Caution
ACE inhibitors like lisinopril can raise potassium; adding potassium supplements can push it too high.
Don't add potassium without provider guidance and monitoring.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Compound-pair rule
Caution
Amantadine can cause orthostatic hypotension; adding an ACE inhibitor may drop blood pressure further, especially on standing.
Watch for dizziness on standing. Rise slowly. Report lightheadedness or fainting to your clinician.
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
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