Amlodipine is a medication belonging to the class of dihydropyridine calcium channel blockers. It is primarily used to treat hypertension (high blood pressure) and various forms of angina (chest pain). Amlodipine works by relaxing blood vessels, thereby reducing the workload on the heart and improving blood flow. It is available as an oral tablet, often prescribed for once-daily dosing. As a prescription medication, its use must be directed and supervised by a licensed healthcare professional. (DrugBank, MedlinePlus)
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Compound-pair rule
Caution
Amantadine plus a calcium-channel blocker can additively lower blood pressure and cause dizziness or ankle swelling.
Monitor BP at home. Rise slowly. Tell your clinician if you feel lightheaded.
DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
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DoseRoutine. (2026). Amlodipine — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/amlodipine
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