Can you take Levothyroxine and Magnesium Oxide together?
Yes, with care — this combination needs a precaution.
Levothyroxine and Magnesium Oxide can be taken together, but the combination needs a precaution.
Why these two interact
Divalent cations chelate levothyroxine in the gut and reduce absorption by up to 30%.
What to do about it
Take levothyroxine on empty stomach; separate mineral supplements by at least 4 hours.
Timing
Separate Levothyroxine and Magnesium Oxide by at least 4 hours. Taking them in the same window is what causes the issue, not taking them on the same day.
The two items in this pair
Levothyroxine
- Category:
- medication
- Typical timing:
- morning
- With food:
- empty_stomach
Magnesium Oxide
- Category:
- mineral
- Typical timing:
- bedtime
- With food:
- either
- Half-life:
- 6 h
Check your whole routine, not just this pair
One pair rarely tells the whole story. DoseRoutine checks every combination in your stack at once — supplements, TRT, peptides, GLP-1s and prescriptions — and schedules the doses so timing conflicts like this one are handled automatically.
Frequently asked
Related combinations
- Ashwagandha and LevothyroxineNote
- Ashwagandha KSM-66 and LevothyroxineNote
- Calcium and LevothyroxineCaution
- Esomeprazole and LevothyroxineCaution
- Iron (ferrous bisglycinate) and LevothyroxineCaution
- Lansoprazole and LevothyroxineCaution
- Levothyroxine and Magnesium CitrateCaution
- Levothyroxine and Magnesium GlycinateCaution
Educational information only, not medical advice. DoseRoutine does not diagnose or treat. Talk to your prescriber before starting, stopping or combining anything — especially if you take prescription medication or are pregnant or breastfeeding.