Can you take Duloxetine and St John's Wort together?
Not together — this combination should be avoided.
Duloxetine and St John's Wort should not be taken together without medical supervision.
Why these two interact
St John's Wort has serotonergic activity and induces CYP3A4, altering SSRI levels.
What to do about it
Avoid combining.
Timing
Separating the doses does not solve this one. The concern is the combined effect in the body, not absorption timing, so spacing them out is not a workaround.
The two items in this pair
Duloxetine
- Category:
- medication
- Typical timing:
- morning
- With food:
- either
- Half-life:
- 12 h
St John's Wort
- Category:
- supplement
- Typical timing:
- morning
- With food:
- either
- Half-life:
- 24 h
Check your whole routine, not just this pair
One pair rarely tells the whole story. DoseRoutine checks every combination in your stack at once — supplements, TRT, peptides, GLP-1s and prescriptions — and schedules the doses so timing conflicts like this one are handled automatically.
Frequently asked
Related combinations
Educational information only, not medical advice. DoseRoutine does not diagnose or treat. Talk to your prescriber before starting, stopping or combining anything — especially if you take prescription medication or are pregnant or breastfeeding.