Can you take Amantadine and St John's Wort together?
Yes, with care — this combination needs a precaution.
Amantadine and St John's Wort can be taken together, but the combination needs a precaution.
Why these two interact
St Johns wort is serotonergic and CNS-active; theoretical additive stimulation with amantadine.
What to do about it
Avoid combining unless cleared by your clinician.
Timing
No fixed separation window applies here. Keep the timing consistent day to day so any effect is easy to spot.
The two items in this pair
Amantadine
- Category:
- medication
- Typical timing:
- morning
- With food:
- either
- Half-life:
- 15 h
St John's Wort
- Category:
- supplement
- Typical timing:
- morning
- With food:
- either
- Half-life:
- 24 h
Check your whole routine, not just this pair
One pair rarely tells the whole story. DoseRoutine checks every combination in your stack at once — supplements, TRT, peptides, GLP-1s and prescriptions — and schedules the doses so timing conflicts like this one are handled automatically.
Frequently asked
Sources
- NIH NCCIH
Related combinations
Educational information only, not medical advice. DoseRoutine does not diagnose or treat. Talk to your prescriber before starting, stopping or combining anything — especially if you take prescription medication or are pregnant or breastfeeding.