Can you take Sertraline and Tranylcypromine together?
Not together — this combination should be avoided.
Sertraline and Tranylcypromine should not be taken together without medical supervision.
Why these two interact
Combining SSRIs/SNRIs with MAOIs can cause life-threatening serotonin syndrome.
What to do about it
Do not combine. Allow at least 14 days between stopping one and starting the other (5 weeks for fluoxetine).
Timing
Separating the doses does not solve this one. The concern is the combined effect in the body, not absorption timing, so spacing them out is not a workaround.
The two items in this pair
Tranylcypromine
- Category:
- medication
- Typical timing:
- morning
- With food:
- either
- Half-life:
- 2.5 h
Check your whole routine, not just this pair
One pair rarely tells the whole story. DoseRoutine checks every combination in your stack at once — supplements, TRT, peptides, GLP-1s and prescriptions — and schedules the doses so timing conflicts like this one are handled automatically.
Frequently asked
Related combinations
Educational information only, not medical advice. DoseRoutine does not diagnose or treat. Talk to your prescriber before starting, stopping or combining anything — especially if you take prescription medication or are pregnant or breastfeeding.