Can you take Levothyroxine and Omeprazole (Prilosec) together?
Yes, with care — this combination needs a precaution.
Levothyroxine and Omeprazole (Prilosec) can be taken together, but the combination needs a precaution.
Why these two interact
Reduced gastric acid impairs levothyroxine absorption.
What to do about it
Monitor TSH after starting/stopping PPI; dose adjustment may be needed.
Timing
No fixed separation window applies here. Keep the timing consistent day to day so any effect is easy to spot.
The two items in this pair
Levothyroxine
- Category:
- medication
- Typical timing:
- morning
- With food:
- empty_stomach
Omeprazole (Prilosec)
- Category:
- medication
- Typical timing:
- morning
- With food:
- empty_stomach
- Half-life:
- 1 h
Check your whole routine, not just this pair
One pair rarely tells the whole story. DoseRoutine checks every combination in your stack at once — supplements, TRT, peptides, GLP-1s and prescriptions — and schedules the doses so timing conflicts like this one are handled automatically.
Frequently asked
Related combinations
- Ashwagandha and LevothyroxineNote
- Ashwagandha KSM-66 and LevothyroxineNote
- Calcium and LevothyroxineCaution
- Esomeprazole and LevothyroxineCaution
- Iron (ferrous bisglycinate) and LevothyroxineCaution
- Lansoprazole and LevothyroxineCaution
- Levothyroxine and Magnesium CitrateCaution
- Levothyroxine and Magnesium GlycinateCaution
Educational information only, not medical advice. DoseRoutine does not diagnose or treat. Talk to your prescriber before starting, stopping or combining anything — especially if you take prescription medication or are pregnant or breastfeeding.