peptide

Matrixyl

Also known as: Palmitoyl Pentapeptide-4

Evidence: High · 100%
Chemical structure of Matrixyl (PubChem CID 9897237)
Structure via PubChem
Half-life
1 h
Typical timing
any
Food rule
either
Default unit
mg

Studied for

Overview

Matrixyl, also known as Palmitoyl Pentapeptide-4 (or Palmitoyl Pentapeptide-3 in older literature), is a synthetic peptide widely used in anti-aging cosmetic formulations. It is derived from a fragment of collagen I, one of the most abundant proteins in the skin. The name "Matrixyl" is a registered trademark of Sederma, a Givaudan company, which introduced this ingredient to the cosmetics market. Its primary function in skincare is to signal to skin cells (fibroblasts) to produce more collagen and other extracellular matrix components, thereby helping to reduce the appearance of fine lines and wrinkles and improve skin texture. It is a small molecule that can penetrate the skin's outer layers to exert its effects. Unlike some other anti-aging ingredients, Matrixyl is generally well-tolerated and can be used on sensitive skin.

Deep dive

Tap a section to expand.

Known interactions

  • Category rule: peptide × hormone
    Note

    Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.

    Track bloodwork with a provider; don't assume combinations are neutral.

Frequently asked

Sources referenced

["DrugBank", "NIH Office of Dietary Supplements (ODS)", "PubChem (National Center for Biotechnology Information)", "Sederma (manufacturer data)"]

DoseRoutine compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Cite this page

Using this in an article, AI answer, or research note? Please attribute:

DoseRoutine. (2026). Matrixyl — Overview, Benefits & Side Effects. Retrieved from https://doseroutine.com/library/matrixyl
Canonical URL

Related compounds

Others in the peptide category or studied for the same goals.

Related benefits

Other compounds studied for the same benefits as Matrixyl.

Continue exploring

See every compound DoseRoutine catalogues for these goals.

Track Matrixyl in DoseRoutine

Add it to your stack. We'll schedule doses, check interactions against everything else you take, and remind you at the right time.

Sign up free →